In the tumour microenvironment (TME), immunogenic cell death (ICD) plays a major role in
stimulating the dysfunctional antitumour immune system. Chronic exposure of damage …

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable
manner, as a result of their immediate structural breakdown. Such an unavoidable variant of …

Background Modulation of adaptive immunity may underscore the efficacy of trans-arterial
chemoembolization (TACE). We evaluated the influence of TACE on T-cell function by …

Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune
response, whereas other DNA-damaging agents such as etoposide and mitomycin C do not …

A large body of evidence supports the idea that accumution of mutant APC alleles in affected
kindreds (Groden lated genetic changes underlie the development of neoet al., 1991; …

APOPTOSIS is a genetically encoded programme of cell death that can be activated under
physiological conditions1, 2 and may be an important safeguard against tumour …

Using confocal microscopy, onset of the mitochondrial permeability transition (MPT) in
individual mitochondria within living cells can be visualized by the redistribution of the …

THE interaction of cells with the extracellular matrix regulates cell shape, motility, growth,
survival, differentiation and gene expression, through integrin-mediated signal transduction1 …

The expansion of GAG triplet repeats in the translated region of the human HD gene,
encoding a protein (huntingtin) of unknown function, is a dominant mutation leading to …

Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the
maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years …