The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Neuroinflammation is a critical factor in developing and progressing numerous brain
diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation …

NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

Metabolic reprogramming is one of the most important hallmarks of malignant tumors.
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …

Deregulated de novo lipid synthesis (DNLS) is a potential druggable vulnerability in
glioblastoma (GBM), a highly lethal and incurable cancer. Yet the molecular mechanisms …

Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an
important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs …

As one of the two highly conserved cellular degradation systems, autophagy plays a critical
role in regulation of protein, lipid, and organelle quality control and cellular homeostasis …