AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics which
coordinates metabolism by phosphorylating a plethora of substrates throughout the cell. But …

Obesity and substantially increased risk of metabolic diseases have become a global
epidemic. microRNAs have attracted a great deal of attention as a potential therapeutic …

Mitochondrial dysfunction is a salient feature of myocardial ischemia/reperfusion injury
(MIRI), while the potential mechanism of mitochondrial dynamics disorder remains unclear …

Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), and spinal
muscular atrophy (SMA) are the most prevalent neuromuscular disorders (NMDs) in children …

Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …

Upregulation of glycolysis, induction of epithelial–mesenchymal transition (EMT) and
macroautophagy (hereafter autophagy), are phenotypic changes that occur in tumor cells, in …

Macroautophagy (hereafter autophagy) is a catabolic process through which cytosolic
components are captured in the autophagosome and degraded in the lysosome. Autophagy …

Liver metastasis is the most fatal event of colon cancer patients. Warburg effect has been
long challenged by the fact of upregulated oxidative phosphorylation (OXPHOS), while its …

Abstract Liver kinase B1 (LKB1), an evolutionarily conserved serine/threonine kinase, is a
master regulator of the AMPK subfamily and controls cellular events such as polarity …

The yeast Snf1/AMP-activated kinase (AMPK) maintains energy homeostasis, controlling
metabolic processes and glucose derepression in response to nutrient levels and …