[HTML][HTML] Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

J Feng, J Li, L Wu, Q Yu, J Ji, J Wu, W Dai… - Journal of Experimental & …, 2020 - Springer
Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …

The enhancement of glycolysis regulates pancreatic cancer metastasis

J Yang, B Ren, G Yang, H Wang, G Chen, L You… - Cellular and Molecular …, 2020 - Springer
Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …

[PDF][PDF] A comprehensive pan-cancer molecular study of gynecologic and breast cancers

AC Berger, A Korkut, RS Kanchi, AM Hegde, W Lenoir… - Cancer cell, 2018 - cell.com
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of
four gynecological types plus breast. Our aims were to identify shared and unique molecular …

[HTML][HTML] Glucose metabolism and glucose transporters in breast cancer

E Shin, JS Koo - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

[HTML][HTML] Targeting glucose metabolism to overcome resistance to anticancer chemotherapy in breast cancer

E Varghese, SM Samuel, A Líšková, M Samec… - Cancers, 2020 - mdpi.com
Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with
distinct phenotypical and morphological characteristics. These are based on their gene …

Emerging roles of aerobic glycolysis in breast cancer

Z Wu, J Wu, Q Zhao, S Fu, J Jin - Clinical and Translational Oncology, 2020 - Springer
Altered aerobic glycolysis is a well-recognized characteristic of cancer cell energy
metabolism, known as the Warburg effect. Even in the presence of abundant oxygen, a …

[HTML][HTML] Role of PFKFB3 and PFKFB4 in cancer: genetic basis, impact on disease development/progression, and potential as therapeutic targets

K Kotowski, J Rosik, F Machaj, S Supplitt, D Wiczew… - Cancers, 2021 - mdpi.com
Simple Summary Recently, our understanding of PFK-2 isozymes, particularly with regards
to their roles in cancer, has developed significantly. This review aims to compile the most …

The emerging role of targeting cancer metabolism for cancer therapy

P Farhadi, R Yarani, S Dokaneheifard… - Tumor …, 2020 - journals.sagepub.com
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer
cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce …

Treatment against glucose-dependent cancers through metabolic PFKFB3 targeting of glycolytic flux

BC Jones, PR Pohlmann, R Clarke… - Cancer and Metastasis …, 2022 - Springer
Reprogrammed metabolism and high energy demand are well-established properties of
cancer cells that enable tumor growth. Glycolysis is a primary metabolic pathway that …

[HTML][HTML] The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma

F Xu, Y Guan, L Xue, S Huang, K Gao, Z Yang… - BMC cancer, 2020 - Springer
Background Glycolysis is a central metabolic pathway for tumor cells. However, the potential
roles of glycolysis-related genes in renal cell carcinoma (RCC) have not been investigated …