Tissue-resident macrophages have pivotal functions for tissue defense and homeostasis.
Two main discoveries have changed our current understanding of macrophage …

Evidence of the diversity and multi-layered organization of the hematopoietic system is
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …

Abstract Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of
the renin–angiotensin–aldosterone system (RAAS) in regulating the conversion of …

Hematopoiesis occurs in distinct waves." Definitive" hematopoietic stem cells (HSCs) with
the potential for all blood lineages emerge in the aorta-gonado-mesonephros, while" …

Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to
respond to inflammatory or infectious etiologies and are crucial participants in the proper …

The third and fourth weeks of gestation in primates are marked by several developmental
milestones, including gastrulation and the formation of organ primordia. However, our …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for
revascularization strategies. Despite these promising results, widespread clinical …

The salivary glands often become damaged in individuals receiving radiotherapy for head
and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their …

The current view of hematopoiesis considers leukocytes on a continuum with distinct
developmental origins, and which exert non-overlapping functions. However, there is less …