Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects
very preterm infants. Although advances in perinatal care have enabled the survival of …

Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

Embryonic lung development requires reciprocal endodermal-mesodermal interactions;
mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the …

Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, with
appreciable morbidity and mortality in a neonatal intensive care setting. Much interest has …

Exposure to hyperoxia, invasive mechanical ventilation, and systemic/local sepsis are
important antecedents of postnatal inflammation in the pathogenesis of bronchopulmonary …

Objective Neonatal hypoxia occurs in approximately 60% of premature births and is
associated with a multitude of neurological disorders. While various treatments have been …

Since Northway's original description of BPD almost 45 years ago, the clinical presentation
of BPD has evolved into a disease process, which mostly involves extremely premature …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with a median
survival of 3 years after diagnosis. Although the etiology of IPF is unknown, it is …

Hyperoxia-induced lung injury plays a key role in the development of bronchopulmonary
dysplasia (BPD), characterized by inflammatory injury and impaired lung development in …

Hyperoxia plays a key role in the development of bronchopulmonary dysplasia (BPD), a
chronic lung disease of preterm infants. Infants with BPD often have brain injury that leads to …