Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and
processes. It modulates and signals the redox metabolism of cells by acting as a messenger …

As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …

Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and
structure data have radically transformed computational protein design. New methods …

Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …

Bioremediation refers to cost-effective and environment-friendly method for converting the
toxic, recalcitrant pollutants into environmentally benign products through the action of …

Enzymes as catalysts in synthetic organic chemistry gained importance in the latter half of
the 20th century, but nevertheless suffered from two major limitations. First, many enzymes …

Hydrocarbons are relatively recalcitrant compounds and are classified as high-priority
pollutants. However, these compounds are slowly degraded by a large variety of …

Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …