Astrocytic transcriptional and epigenetic mechanisms of drug addiction

LM Holt, EJ Nestler - Journal of Neural Transmission, 2024 - Springer
Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …

[HTML][HTML] A Review of Research on the Association between Neuron–Astrocyte Signaling Processes and Depressive Symptoms

J Yao, C Chen, Y Guo, Y Yang, X Liu, S Chu… - International Journal of …, 2023 - mdpi.com
Depression is a mental illness that has a serious negative impact on physical and mental
health. The pathophysiology of depression is still unknown, and therapeutic medications …

[HTML][HTML] Prefrontal cortex astroglia modulate anhedonia-like behavior

SA Codeluppi, M Xu, Y Bansal, AE Lepack… - Molecular …, 2023 - nature.com
Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently
found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress …

[HTML][HTML] Changes at glutamate tripartite synapses in the prefrontal cortex of a new animal model of resilience/vulnerability to acute stress

T Bonifacino, J Mingardi, R Facchinetti, N Sala… - Translational …, 2023 - nature.com
Stress represents a main risk factor for psychiatric disorders. Whereas it is known that even a
single trauma may induce psychiatric disorders in humans, the mechanisms of vulnerability …

[HTML][HTML] Astrocytes underlie a faster-onset antidepressant effect of hypidone hydrochloride (YL-0919)

JF Li, WY Hu, HX Chang, JH Bao, XX Kong… - Frontiers in …, 2023 - frontiersin.org
Introduction: Major depression disorder (MDD) is a common and potentially life-threatening
mental illness; however, data on its pathogenesis and effective therapeutic measures are …

[HTML][HTML] Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders

C Cervetto, G Maura, D Guidolin, S Amato, C Ceccoli… - …, 2023 - Elsevier
It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …

Alterations in astrocytic regulation of excitation and inhibition by stress exposure and in severe psychopathology

D Kaul, SG Schwab, N Mechawar, L Ooi… - Journal of …, 2022 - Soc Neuroscience
Dysregulation of excitatory and inhibitory signaling is commonly observed in major
psychiatric disorders, including schizophrenia, depression, and bipolar disorder, and is often …

Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom

PW Kalivas, SL Gourley, MP Paulus - Neuroscience & Biobehavioral …, 2023 - Elsevier
Spontaneous thought is an adaptive cognitive process that can produce novel and insightful
thought sequences useful in guiding future behavior. In many psychiatric disorders …

[HTML][HTML] Serum levels of S100B protein and myelin basic protein as a potential biomarkers of recurrent depressive disorders

LA Levchuk, OV Roschina, EV Mikhalitskaya… - Journal of Personalized …, 2023 - mdpi.com
Nowadays, nervous tissue damage proteins in serum are considered promising drug targets
and biomarkers of Mood Disorders. In a cross-sectional naturalistic study, the S100B, MBP …

[HTML][HTML] Non-Opioid Anesthetics Addiction: A Review of Current Situation and Mechanism

L Deng, L Wu, R Gao, X Xu, C Chen, J Liu - Brain Sciences, 2023 - mdpi.com
Drug addiction is one of the major worldwide health problems, which will have serious
adverse consequences on human health and significantly burden the social economy and …