Astrocytic transcriptional and epigenetic mechanisms of drug addiction
LM Holt, EJ Nestler - Journal of Neural Transmission, 2024 - Springer
Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …
current neuroscience research. Drug-induced lasting changes in gene expression are …
[HTML][HTML] A Review of Research on the Association between Neuron–Astrocyte Signaling Processes and Depressive Symptoms
J Yao, C Chen, Y Guo, Y Yang, X Liu, S Chu… - International Journal of …, 2023 - mdpi.com
Depression is a mental illness that has a serious negative impact on physical and mental
health. The pathophysiology of depression is still unknown, and therapeutic medications …
health. The pathophysiology of depression is still unknown, and therapeutic medications …
[HTML][HTML] Prefrontal cortex astroglia modulate anhedonia-like behavior
SA Codeluppi, M Xu, Y Bansal, AE Lepack… - Molecular …, 2023 - nature.com
Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently
found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress …
found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress …
[HTML][HTML] Changes at glutamate tripartite synapses in the prefrontal cortex of a new animal model of resilience/vulnerability to acute stress
T Bonifacino, J Mingardi, R Facchinetti, N Sala… - Translational …, 2023 - nature.com
Stress represents a main risk factor for psychiatric disorders. Whereas it is known that even a
single trauma may induce psychiatric disorders in humans, the mechanisms of vulnerability …
single trauma may induce psychiatric disorders in humans, the mechanisms of vulnerability …
[HTML][HTML] Astrocytes underlie a faster-onset antidepressant effect of hypidone hydrochloride (YL-0919)
JF Li, WY Hu, HX Chang, JH Bao, XX Kong… - Frontiers in …, 2023 - frontiersin.org
Introduction: Major depression disorder (MDD) is a common and potentially life-threatening
mental illness; however, data on its pathogenesis and effective therapeutic measures are …
mental illness; however, data on its pathogenesis and effective therapeutic measures are …
[HTML][HTML] Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders
It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …
that a neurocentric perspective of the integrative signal communication in the central …
Alterations in astrocytic regulation of excitation and inhibition by stress exposure and in severe psychopathology
Dysregulation of excitatory and inhibitory signaling is commonly observed in major
psychiatric disorders, including schizophrenia, depression, and bipolar disorder, and is often …
psychiatric disorders, including schizophrenia, depression, and bipolar disorder, and is often …
Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom
PW Kalivas, SL Gourley, MP Paulus - Neuroscience & Biobehavioral …, 2023 - Elsevier
Spontaneous thought is an adaptive cognitive process that can produce novel and insightful
thought sequences useful in guiding future behavior. In many psychiatric disorders …
thought sequences useful in guiding future behavior. In many psychiatric disorders …
[HTML][HTML] Serum levels of S100B protein and myelin basic protein as a potential biomarkers of recurrent depressive disorders
LA Levchuk, OV Roschina, EV Mikhalitskaya… - Journal of Personalized …, 2023 - mdpi.com
Nowadays, nervous tissue damage proteins in serum are considered promising drug targets
and biomarkers of Mood Disorders. In a cross-sectional naturalistic study, the S100B, MBP …
and biomarkers of Mood Disorders. In a cross-sectional naturalistic study, the S100B, MBP …
[HTML][HTML] Non-Opioid Anesthetics Addiction: A Review of Current Situation and Mechanism
L Deng, L Wu, R Gao, X Xu, C Chen, J Liu - Brain Sciences, 2023 - mdpi.com
Drug addiction is one of the major worldwide health problems, which will have serious
adverse consequences on human health and significantly burden the social economy and …
adverse consequences on human health and significantly burden the social economy and …