The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

The success of anti-retroviral therapy has improved the quality of life and lifespan of HIV+
individuals, transforming HIV infection into a chronic condition. These improvements have …

Nicotine is considered an important component of tobacco responsible for the smoking habit
in humans. Nicotine increases glutamate-mediated transmission throughout brain reward …

Background: Repeated alcohol administration alters nucleus accumbens (NAC) basal
glutamate content and sensitizes the capacity of alcohol to increase NAC extracellular …

Despite the success of combination anti-retroviral therapy (cART), around 50% of HIV-
infected individuals still display a variety of neuropathological and neurocognitive sequelae …

Abstract Rationale The Scheduled High Alcohol Consumption (SHAC) binge drinking model
is a simple, partial murine model with which to investigate some of the neurobiological …

Background Perivascular macrophages and microglia are critical to CNS function. Drugs of
abuse increase extracellular dopamine in the CNS, exposing these cells to elevated levels …

Central nervous system (CNS) complications resulting from HIV infection remain a major
public health problem as individuals live longer due to the success of combined …

Induction of innate immune genes in the brain is thought to be a major factor in the
development of addiction to substances of abuse. As the major component of the innate …

Accumulating evidence indicates that the serotonin system modulates the behavioral and
neurochemical effects of cocaine, but the receptor subtypes mediating these effects remain …