Radiation can cause as well as cure cancer. The risk of developing radiation-induced
cancer has traditionally been estimated from cancer incidence among survivors of the …

Neutron-based experimental techniques have been continuously improved, refined and
strengthened since the pioneering experiments conducted by Clifford Shull and Bertram …

Clustered DNA damage is related to the biological effects of ionizing radiation. However, its
precise yield and complexity (ie, number of lesions per damaged site) in vivo remain …

The objective of our study was to assess the radioprotective effect of flavonoids extracted
from Rosa roxburghii Tratt (FRT) and investigate the role of Bcl-2 (Ca 2+)/Caspase-3/PARP …

Clustered DNA damage induced by 10, 20 and 30 MeV protons in pBR322 plasmid DNA
was investigated. Besides determination of strand breaks, additional lesions were detected …

We present a nanodosimetric model for predicting the yield of double strand breaks (DSBs)
and non-DSB clustered damages induced in irradiated DNA. The model uses experimental …

Background and Purpose To understand the mechanisms involved in the strong killing effect
of carbon-ion beam irradiation on cancer cells with TP53 tumor suppressor gene …

Ionizing radiation induces multiple damaged sites (clustered damage) together with isolated
lesions in DNA. Clustered damage consists of closely spaced lesions within a few helical …

In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas
cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant …

PURPOSE: The high relative biologic effectiveness (RBE) of high-linear energy transfer
(LET) heavy-ion radiation has enabled powerful radiotherapy. The potential risk of later …