Formation of clustered DNA damage after high-LET irradiation: a review
M Hada, AG Georgakilas - Journal of radiation research, 2008 - ieeexplore.ieee.org
Radiation can cause as well as cure cancer. The risk of developing radiation-induced
cancer has traditionally been estimated from cancer incidence among survivors of the …
cancer has traditionally been estimated from cancer incidence among survivors of the …
Neutron detection techniques from μeV to GeV
A Pietropaolo, M Angelone, R Bedogni, N Colonna… - Physics Reports, 2020 - Elsevier
Neutron-based experimental techniques have been continuously improved, refined and
strengthened since the pioneering experiments conducted by Clifford Shull and Bertram …
strengthened since the pioneering experiments conducted by Clifford Shull and Bertram …
Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy
T Nakano, K Akamatsu, M Tsuda… - Proceedings of the …, 2022 - National Acad Sciences
Clustered DNA damage is related to the biological effects of ionizing radiation. However, its
precise yield and complexity (ie, number of lesions per damaged site) in vivo remain …
precise yield and complexity (ie, number of lesions per damaged site) in vivo remain …
Flavonoids of Rosa roxburghii Tratt exhibit radioprotection and anti-apoptosis properties via the Bcl-2(Ca2+)/Caspase-3/PARP-1 pathway
P Xu, X Cai, W Zhang, Y Li, P Qiu, D Lu, X He - Apoptosis, 2016 - Springer
The objective of our study was to assess the radioprotective effect of flavonoids extracted
from Rosa roxburghii Tratt (FRT) and investigate the role of Bcl-2 (Ca 2+)/Caspase-3/PARP …
from Rosa roxburghii Tratt (FRT) and investigate the role of Bcl-2 (Ca 2+)/Caspase-3/PARP …
Proton-induced direct and indirect damage of plasmid DNA
L Vyšín, K Pachnerová Brabcová, V Štěpán… - Radiation and …, 2015 - Springer
Clustered DNA damage induced by 10, 20 and 30 MeV protons in pBR322 plasmid DNA
was investigated. Besides determination of strand breaks, additional lesions were detected …
was investigated. Besides determination of strand breaks, additional lesions were detected …
A nanodosimetric model of radiation-induced clustered DNA damage yields
G Garty, R Schulte, S Shchemelinin… - Physics in Medicine …, 2010 - iopscience.iop.org
We present a nanodosimetric model for predicting the yield of double strand breaks (DSBs)
and non-DSB clustered damages induced in irradiated DNA. The model uses experimental …
and non-DSB clustered damages induced in irradiated DNA. The model uses experimental …
Carbon-ion beam irradiation kills X-ray-resistant p53-null cancer cells by inducing mitotic catastrophe
N Amornwichet, T Oike, A Shibata, H Ogiwara… - PLoS …, 2014 - journals.plos.org
Background and Purpose To understand the mechanisms involved in the strong killing effect
of carbon-ion beam irradiation on cancer cells with TP53 tumor suppressor gene …
of carbon-ion beam irradiation on cancer cells with TP53 tumor suppressor gene …
Quantitative analysis of isolated and clustered DNA damage induced by gamma-rays, carbon ion beams, and iron ion beams
H Terato, R Tanaka, Y Nakaarai, T Nohara… - Journal of radiation …, 2008 - jstage.jst.go.jp
Ionizing radiation induces multiple damaged sites (clustered damage) together with isolated
lesions in DNA. Clustered damage consists of closely spaced lesions within a few helical …
lesions in DNA. Clustered damage consists of closely spaced lesions within a few helical …
Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin
D Kobayashi, T Oike, A Shibata, A Niimi, Y Kubota… - Scientific reports, 2017 - nature.com
In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas
cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant …
cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant …
High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations
T Imaoka, M Nishimura, S Kakinuma, Y Hatano… - International Journal of …, 2007 - Elsevier
PURPOSE: The high relative biologic effectiveness (RBE) of high-linear energy transfer
(LET) heavy-ion radiation has enabled powerful radiotherapy. The potential risk of later …
(LET) heavy-ion radiation has enabled powerful radiotherapy. The potential risk of later …