The phylogenetically ancient SLC26 gene family encodes multifunctional anion exchangers
and anion channels transporting a broad range of substrates, including Cl−, HCO3−, sulfate …

Most secretory proteins travel through a well-documented conventional secretion pathway
involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has …

The human SLC26 transporter family exhibits various transport characteristics, and family
member SLC26A9 performs multiple roles, including acting as Cl–/HCO3–exchangers, Cl …

Pendred syndrome is an autosomal recessive disorder characterized by sensorineural
deafness, goiter and a partial defect in iodide organification. Goiter development and …

Hearing loss with enlargement of the vestibular aqueduct (EVA) can be associated with
mutations of the SLC26A4 gene encoding pendrin, a transmembrane Cl−/I−/HCO …

Mutations in SLC26A4 cause a broad phenotypic spectrum, from typical Pendred syndrome
to nonsyndromic hearing loss associated with enlarged vestibular aqueduct. Identification of …

Background Mutations in SLC26A4, which encodes pendrin, are a common cause of
deafness. SLC26A4 mutations are responsible for Pendred syndrome and non-syndromic …

Maintaining the integrity of cellular membranes is critical to protecting metabolic activities
and genetic information from the environment. Regulation of transport across membranes of …

Abstract Bicarbonate (HCO3−) has a central place in human physiology as the waste
product of mitochondrial energy production and for its role in pH buffering throughout the …

Under ER stress conditions, the ER form of transmembrane proteins can reach the plasma
membrane via a Golgi‐independent unconventional protein secretion (UPS) pathway …