The roles played by cholesterol in cancer development and the potential of therapeutically
targeting cholesterol homeostasis is a controversial area in the cancer community. Several …

Gastric cancer is the second leading cause of cancer-related mortality and the fourth most
common cancer globally. There are, however, distinct differences in incidence rates in …

Deregulated cell proliferation is an established feature of cancer, and altered tumor
metabolism has witnessed renewed interest over the past decade, including the study of …

Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Cardio-oncology has organically developed as a new discipline within cardiovascular
medicine as a result of the cardiac and vascular adverse sequelae of the major advances in …

While the unique metabolic activities of malignant tissues as potential targets for cancer
therapeutics has been the subject of several recent reviews, the role of cholesterol …

A hallmark of cancer cells includes a metabolic reprograming that provides energy, the
essential building blocks, and signaling required to maintain survival, rapid growth …

Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested
in the diet. By modulating the activity of many proteins [eg, liver X receptors (LXRs), oxysterol …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

Cholesterol is essential for cell function and viability. It is a component of the plasma
membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D …