MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer
The drug efflux function of P-glycoprotein (P-gp) encoded by MDR1 can be influenced by
genetic polymorphisms, including two synonymous changes in the coding region of MDR1 …
genetic polymorphisms, including two synonymous changes in the coding region of MDR1 …
[HTML][HTML] Pharmacogenomics and personalized medicine: a review focused on their application in the Chinese population
W Shu, J Li, X Wang, M Huang - Acta pharmacologica Sinica, 2015 - nature.com
The field of pharmacogenomics was initiated in the 1950s and began to thrive after the
completion of the human genome project 10 years ago. Thus far, more than 100 drug labels …
completion of the human genome project 10 years ago. Thus far, more than 100 drug labels …
Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients
Aims: To evaluate the influences of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on
tacrolimus concentration in early postrenal transplant recipients. Patients & methods: A total …
tacrolimus concentration in early postrenal transplant recipients. Patients & methods: A total …
Challenges for drug discovery and development in China
KL Hon, VWY Lee - Expert Opinion on Drug Discovery, 2017 - Taylor & Francis
Introduction: The drug development industry is restructuring worldwide in terms of the
research and development process. As with pharmaceuticals in the west, China faces major …
research and development process. As with pharmaceuticals in the west, China faces major …
Assessment of the cadmium exposure in the blood, diet, and water of the Pumi people in Yunnan, China
Q Wang, YM Feng, SM Wang, YQ Du, JZ Yin… - Biological trace element …, 2015 - Springer
Cadmium (Cd) is considered as one of the most toxic and carcinogenic heavy metals.
Accumulation of Cd in the human body can cause multiorgan dysfunction. Long-term …
Accumulation of Cd in the human body can cause multiorgan dysfunction. Long-term …
[HTML][HTML] Genetic analysis of pharmacogenomic VIP variants in the Wa population from Yunnan Province of China
D Li, L Peng, S Xing, C He, T Jin - BMC Genomic Data, 2021 - Springer
Background The variation of drug responses and target does among individuals is mostly
determined by genes. With the development of pharmacogenetics and pharmacogenomics …
determined by genes. With the development of pharmacogenetics and pharmacogenomics …
[HTML][HTML] I 期临床试验中健康受试者筛选失败原因及影响因素分析
张莉， 孟现民， 董平， 王斌 - 2023 - jms.fudan.edu.cn
目的分析Ⅰ 期临床试验(Phase Ⅰ clinical trial, PⅠCT) 中健康受试者(healthy subject, HS)
筛选失败(screening failure, SF) 的原因及影响因素, 为今后PⅠCT 中HS 筛选提供参考 …
筛选失败(screening failure, SF) 的原因及影响因素, 为今后PⅠCT 中HS 筛选提供参考 …
Assessment of the iodine status of the Wa national boarding school students in southwest China
JZ Yin, YM Feng, SX Wu, XH Zhang, SM Wang… - Biological trace element …, 2014 - Springer
Iodine deficiency disorder (IDD) has been recognized as a major public health problem
worldwide and has serious detrimental effects on the growth and development of the …
worldwide and has serious detrimental effects on the growth and development of the …