Early detection of cancer
Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …
[HTML][HTML] Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
[HTML][HTML] Pathological angiogenesis: mechanisms and therapeutic strategies
AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …
existing ones, is an essential process for growth and development. Different mechanisms …
[HTML][HTML] Tumor angiogenesis: causes, consequences, challenges and opportunities
R Lugano, M Ramachandran, A Dimberg - Cellular and Molecular Life …, 2020 - Springer
Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …
vary between tumor type and anatomic location, but also occur simultaneously within the …
[HTML][HTML] Chitinase-3 like-protein-1 function and its role in diseases
T Zhao, Z Su, Y Li, X Zhang, Q You - Signal Transduction and Targeted …, 2020 - nature.com
Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …
[HTML][HTML] Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments
X Wei, Y Chen, X Jiang, M Peng, Y Liu, Y Mo, D Ren… - Molecular cancer, 2021 - Springer
Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …
found in many malignant tumors, and is different from the traditional angiogenetic process …
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
Microenvironmental regulation of tumour angiogenesis
M De Palma, D Biziato, TV Petrova - Nature Reviews Cancer, 2017 - nature.com
Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …
[HTML][HTML] Shaping the brain vasculature in development and disease in the single-cell era
T Wälchli, J Bisschop, P Carmeliet, G Zadeh… - Nature Reviews …, 2023 - nature.com
The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …
Progress and prospects of early detection in lung cancer
S Blandin Knight, PA Crosbie, H Balata… - Open …, 2017 - royalsocietypublishing.org
Lung cancer is the leading cause of cancer-related death in the world. It is broadly divided
into small cell (SCLC, approx. 15% cases) and non-small cell lung cancer (NSCLC, approx …
into small cell (SCLC, approx. 15% cases) and non-small cell lung cancer (NSCLC, approx …