In recent decades, antiangiogenic therapy, which blocks the supply of oxygen and nutrition
to tumor cells, has become a promising clinical strategy for the treatment of patients with …

Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with low five-year
survival rates. Recently described molecular phenotypes of SCLC exhibit differential …

Vasculogenic mimicry (VM), a vessel-like structure independent of endothelial cells,
commonly exists in solid tumors which requires blood vessels to grow. As a special source …

Mechanistic models of biological processes can explain observed phenomena and predict
responses to a perturbation. A mathematical model is typically constructed using expert …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. Its
aggressiveness is driven by an intense fibrotic desmoplastic reaction in which the …

Small-cell lung cancer (SCLC) cases represent approximately 15% of all lung cancer cases,
remaining a recalcitrant malignancy with poor survival and few treatment options. In the last …

We propose a new cadherin family classification comprising epithelial cadherins (cadherin
17 [CDH17], cadherin 16, VE-cadherin, cadherin 6 and cadherin 20) containing RGD motifs …

Vasculogenic mimicry (VM) is the formation of a “vessel-like” structure without endothelial
cells. VM exists in vascular-dependent solid tumors and is a special blood supply source …

Small cell lung cancer (SCLC) is a highly aggressive and lethal malignancy. Despite high
initial response rates to systemic chemotherapy, the disease eventually relapses; further …

Hypoxia mediates resistance to radio (chemo) therapy (RT) by stimulating the synthesis of
hypoxia-related genes, such as osteopontin (OPN) and stress proteins, including the major …