Head and neck cancer

A Argiris, MV Karamouzis, D Raben, RL Ferris - The Lancet, 2008 - thelancet.com
Most head and neck cancers are squamous cell carcinomas that develop in the upper
aerodigestive epithelium after exposure to carcinogens such as tobacco and alcohol …

Human papillomavirus in oropharyngeal cancer: The changing face of a disease

J Mallen-St Clair, M Alani, MB Wang… - Biochimica et Biophysica …, 2016 - Elsevier
The last decade has brought about an unexpected rise in oropharyngeal squamous cell
carcinoma (OPSCC) primarily in white males from the ages of 40–55 years, with limited …

A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

LB Darragh, MM Knitz, J Hu, ET Clambey, J Backus… - Nature Cancer, 2022 - nature.com
Five-year survival for human papilloma virus-unrelated head and neck squamous cell
carcinomas remain below 50%. We assessed the safety of administering combination …

CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway

W Jia, S Chen, R Wei, X Yang, M Zhang, Y Qian… - Scientific Reports, 2023 - nature.com
Head and neck squamous cell carcinoma (HNSC) is the most common malignant tumor of
head and neck. Due to the insidious nature of HNSC and the lack of effective early …

FUT6 inhibits the proliferation, migration, invasion, and EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by regulating EGFR/ERK/STAT …

Q Wang, C Liao, Z Tan, X Li, X Guan, H Li, Z Tian… - Cancer Gene …, 2023 - nature.com
Glycosylation change is one of the landmark events of tumor occurrence and development,
and tumor cells may be inhibited by regulating the aberrant expression of …

CT-based radiomic signatures for predicting histopathologic features in head and neck squamous cell carcinoma

P Mukherjee, M Cintra, C Huang, M Zhou… - Radiology: Imaging …, 2020 - pubs.rsna.org
Purpose To determine the performance of CT-based radiomic features for noninvasive
prediction of histopathologic features of tumor grade, extracapsular spread, perineural …

Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications

P Boscolo-Rizzo, MC Da Mosto, E Rampazzo… - Cancer and Metastasis …, 2016 - Springer
Strongly associated with tobacco use, heavy alcohol consumption, and with high-risk human
papillomavirus (HPV) infection, head and neck squamous cell carcinoma (HNSCC) is a …

GLI3 knockdown decreases stemness, cell proliferation and invasion in oral squamous cell carcinoma

MFSD Rodrigues, L Miguita… - International …, 2018 - spandidos-publications.com
Oral squamous cell carcinoma (OSCC) is an extremely aggressive disease associated with
a poor prognosis. Previous studies have established that cancer stem cells (CSCs) actively …

Promoter methylation of cancer stem cell surface markers as an epigenetic biomarker for prognosis of oral squamous cell carcinoma

YK Han, HY Park, SG Park, JJ Hwang… - International Journal of …, 2022 - mdpi.com
Growing evidence suggests that genetic and epigenetic factors, including environmental
factors, contribute to the development of oral squamous cell carcinoma (OSCC). Here, we …

[HTML][HTML] Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis

YC Wu, CS Huang, MS Hsieh, CM Huang… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Background: Research has demonstrated that some tumor cells can transform into drug-
tolerant persisters (DTPs), which serve as a reservoir for the recurrence of the disease. The …