[HTML][HTML] Organ on chip technology to model cancer growth and metastasis
Organ on chip (OOC) has emerged as a major technological breakthrough and distinct
model system revolutionizing biomedical research and drug discovery by recapitulating the …
model system revolutionizing biomedical research and drug discovery by recapitulating the …
[HTML][HTML] Mitogen-activated protein kinase signaling pathway in oral cancer
Q Peng, Z Deng, H Pan, L Gu, O Liu… - Oncology …, 2018 - spandidos-publications.com
The mitogen-activated protein kinase (MAPK) signaling pathway is associated with tumor
cell proliferation, differentiation, apoptosis, angiogenesis, invasion and metastasis. The …
cell proliferation, differentiation, apoptosis, angiogenesis, invasion and metastasis. The …
3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro
The use of 3D cancer models will have both ethical and economic impact in drug screening
and development, to promote the reduction of the animals employed in preclinical studies …
and development, to promote the reduction of the animals employed in preclinical studies …
Bioengineered tumoral microtissues recapitulate desmoplastic reaction of pancreatic cancer
V Brancato, V Comunanza, G Imparato, D Corà… - Acta biomaterialia, 2017 - Elsevier
Many of the existing three-dimensional (3D) cancer models in vitro fail to represent the entire
complex tumor microenvironment composed of cells and extra cellular matrix (ECM) and do …
complex tumor microenvironment composed of cells and extra cellular matrix (ECM) and do …
Multi compartmental 3D breast cancer disease model–recapitulating tumor complexity in in-vitro
Breast cancer is the most common ailment among women. In 2020, it had the highest
incidence of any type of cancer. Many Phase II and III anti-cancer drugs fail due to efficacy …
incidence of any type of cancer. Many Phase II and III anti-cancer drugs fail due to efficacy …
3D is not enough: Building up a cell instructive microenvironment for tumoral stroma microtissues
We fabricated three-dimensional microtissues with the aim to replicate in vitro the
composition and the functionalities of the tumor microenvironment. By arranging either …
composition and the functionalities of the tumor microenvironment. By arranging either …
Reconstructing the tumor architecture into organoids
Cancer remains a leading health burden worldwide. One of the challenges hindering cancer
therapy development is the substantial discrepancies between the existing cancer models …
therapy development is the substantial discrepancies between the existing cancer models …
Cell microencapsulation techniques for cancer modelling and drug discovery
L Barrett, K Coopman - Artificial Cells, Nanomedicine, and …, 2024 - Taylor & Francis
Cell encapsulation into spherical microparticles is a promising bioengineering tool in many
fields, including 3D cancer modelling and pre-clinical drug discovery. Cancer …
fields, including 3D cancer modelling and pre-clinical drug discovery. Cancer …
Biophysical properties of dermal building-blocks affect extra cellular matrix assembly in 3D endogenous macrotissue
The fabrication of functional tissue units is one of the major challenges in tissue engineering
due to their in vitro use in tissue-on-chip systems, as well as in modular tissue engineering …
due to their in vitro use in tissue-on-chip systems, as well as in modular tissue engineering …
The effect of porosity and stiffness of glutaraldehyde cross-linked egg white scaffold simulating aged extracellular matrix on distribution and aggregation of ovarian …
Z Guo, T Zhang, K Fang, P Liu, M Li, N Gu - Colloids and Surfaces A …, 2016 - Elsevier
The extracellular matrix (ECM) regulates cellular behaviours in a way that it is still far from
completely understood, especially in cancer research field. Here we showed a simple …
completely understood, especially in cancer research field. Here we showed a simple …