[PDF][PDF] Hallmarks of aging: An expanding universe
Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
[PDF][PDF] Meta-hallmarks of aging and cancer
Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
[HTML][HTML] Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
[HTML][HTML] Ageing as a software design flaw
JP de Magalhães - Genome Biology, 2023 - Springer
Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …
[HTML][HTML] Immunosenescence: molecular mechanisms and diseases
Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - Signal transduction and …, 2023 - nature.com
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
[HTML][HTML] Methylation across the central dogma in health and diseases: new therapeutic strategies
R Liu, E Zhao, H Yu, C Yuan, MN Abbas… - Signal Transduction and …, 2023 - nature.com
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
On epigenetic stochasticity, entropy and cancer risk
AE Teschendorff - … Transactions of the Royal Society B, 2024 - royalsocietypublishing.org
Epigenetic changes are known to accrue in normal cells as a result of ageing and
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …
Epigenetic aging in adult neurogenesis
Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …
[HTML][HTML] Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing
M Gómez de Cedrón, R Moreno Palomares… - Frontiers in …, 2023 - frontiersin.org
Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …
[HTML][HTML] The inactive X chromosome accumulates widespread epigenetic variability with age
Y Liu, L Sinke, TH Jonkman, RC Slieker… - Clinical …, 2023 - Springer
Background Loss of epigenetic control is a hallmark of aging. Among the most prominent
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …