Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

Skeletal muscle mass increases during postnatal development through a process of
hypertrophy, ie enlargement of individual muscle fibers, and a similar process may be …

Skeletal muscle is a plastic organ that is maintained by multiple pathways regulating cell
and protein turnover. During muscle atrophy, proteolytic systems are activated, and …

Many pathological states characterized by muscle atrophy (eg, sepsis, cachexia, starvation,
metabolic acidosis and severe insulinopenia) are associated with an increase in circulating …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

Growth and maintenance of skeletal muscle fibres depend on coordinated activation and
return to quiescence of resident muscle stem cells (MuSCs). The transcription factor …

Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the
quality of life of cancer patients, decreases the efficiency of therapeutic strategies and …

Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle
cell differentiation. Myostatin requires both Smad2 and Smad3 downstream of the activin …

Muscle performance is influenced by turnover of contractile proteins. Production of new
myofibrils and degradation of existing proteins is a delicate balance, which, depending on …