Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

[HTML][HTML] Using inorganic nanoparticles to fight fungal infections in the antimicrobial resistant era

T Huang, X Li, M Maier, NM O'Brien-Simpson… - Acta Biomaterialia, 2023 - Elsevier
Fungal infections pose a serious threat to human health and livelihoods. The number and
variety of clinically approved antifungal drugs is very limited, and the emergence and rapid …

[HTML][HTML] Influence of exogenous elicitors on the production of secondary metabolite in plants: A review (“VSI: secondary metabolites”)

A Humbal, B Pathak - Plant Stress, 2023 - Elsevier
During the whole lifespan from seedling to the mature stage, the plant produces a range of
complex compounds usually known as Secondary Metabolites (SMs) for their cellular and …

[图书][B] Natural product biosynthesis

CT Walsh, Y Tang - 2017 - books.google.com
Authored by leading experts in the enzymology of natural product biosynthesis, this textbook
provides a thorough description of the types of natural products, the biosynthetic pathways …

Recent advancements in microbial polysaccharides: Synthesis and applications

YAG Mahmoud, ME El-Naggar, A Abdel-Megeed… - Polymers, 2021 - mdpi.com
Polysaccharide materials are widely applied in different applications including food, food
packaging, drug delivery, tissue engineering, wound dressing, wastewater treatment, and …

A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond

M Pepe, M Hesami, KA de la Cerda, ML Perreault… - Biotechnology …, 2023 - Elsevier
Psychedelic mushrooms containing psilocybin and related tryptamines have long been used
for ethnomycological purposes, but emerging evidence points to the potential therapeutic …

Discovery and engineering of the cocaine biosynthetic pathway

YJ Wang, JP Huang, T Tian, Y Yan… - Journal of the …, 2022 - ACS Publications
Cocaine, the archetypal tropane alkaloid from the plant genus Erythroxylum, has recently
been used clinically as a topical anesthesia of the mucous membranes. Despite this, the key …

Engineered production of strictosidine and analogues in yeast

J Misa, JM Billingsley, K Niwa, RK Yu… - ACS synthetic …, 2022 - ACS Publications
Monoterpene indole alkaloids (MIAs) are an expansive class of plant natural products, many
of which have been named on the World Health Organization's List of Essential Medicines …

Palladium-catalyzed decarboxylation [2+ 2+ 2] annulation approach to chromone-containing polycyclic compounds

YC Fang, JH Chen, RF Xiu, LR Zhang… - Organic Chemistry …, 2023 - pubs.rsc.org
We present herein a palladium-catalyzed decarboxylation [2+ 2+ 2] annulation with 3-
iodochromones, bridged olefins, and o-bromobenzoic acids to give various exo-chromone …