High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Principles and Practice of Sleep Medicine, 5th Edition, by Meir H. Kryger, MD, FRCPC,
Thomas Roth, PhD, and William C. Dement, MD, PhD, delivers the comprehensive …

With the advancement of in vivo magnetic resonance imaging (MRI) technique, more
detailed information about the human brain at high altitude (HA) has been revealed. The …

New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …

Global cerebral blood flow (gCBF) and cerebrovascular reactivity to hypercapnia (CV RCO 2
CVR_CO_2) are modulated by gonadal hormone activity, while insulin‐like growth factor 1 …

Neuronal activity in the brain depends on mostly aerobic generation of energy equivalents
and thus on a constant O 2 supply. Oxygenation of the vertebrate brain has been optimized …

Key points Thermal and hypoxic stress commonly coexist in environmental, occupational
and clinical settings, yet how the brain tolerates these multi‐stressor environments is …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

High-altitude ascent imposes a unique cerebrovascular challenge due to two opposing
blood gas chemostimuli. Specifically, hypoxia causes cerebral vasodilation, whereas …