Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential
for adeno-to-squamous transdifferentiation (AST). However, it remains largely unknown how …

Tumor cells voraciously consume nutrients from their environment to facilitate rapid
proliferation, necessitating effective strategies to manage nutrient scarcity during tumor …

Pancreatic ductal adenocarcinoma (PDAC) is a kind of tumor lacking nutrients due to its
poor vascularity and desmoplasia. Recent studies have shown that cancer cells might …

Due to the lack of a precise in vitro model that can mimic the nature microenvironment in
osteosarcoma, the understanding of its resistance to chemical drugs remains limited. Here …

Lung cancer stands as the most prevalent form of cancer globally, posing a significant threat
to human well-being. Due to the lack of effective and accurate early diagnostic methods …

Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are
known to induce oxidative stress. In the context of cancer development, cancer cells adeptly …

Cadmium (Cd) exposure significantly increases the risk of lung cancer. The demand for
glutamine is increasing in cancers, including lung cancer. In this study, we investigated the …

Cancer stem cells (CSCs) are considered key contributors to tumor progression, and
ferroptosis has been identified as a potential target for CSCs. We have previously shown …

Abnormalities of FGFR1 have been reported in multiple malignancies, suggesting FGFR1 as
a potential target for precision treatment, but drug resistance remains a formidable obstacle …