Recent expansion of our knowledge on epigenetic changes strongly suggests that not only
nuclear DNA (nDNA), but also mitochondrial DNA (mtDNA) may be subjected to epigenetic …

Cell-free circulating DNA carries not only tumor-specific changes in its sequence but also
distinctive epigenetic marks, namely DNA methylation, in certain GC-rich fragments. These …

Purpose: Pancreatic cancer is the fourth leading cause of cancer deaths and there currently
is no reliable modality for the early detection of this disease. Here, we identify cancer …

Epigenetics refers to the study of mechanisms that alter gene expression without altering the
primary DNA sequence. Epigenetic mechanisms are heritable and reversible. Over the last …

The bidirectional cross talk between nuclear and mitochondrial DNA is essential for cellular
homeostasis and proper functioning. Mitochondria depend on nuclear contribution for much …

The critical point for successful treatment of cancer is diagnosis at early stages of tumor
development. Cancer cell‐specific methylated DNA has been found in the blood of cancer …

Epigenetic alterations hold great promise as biomarkers for early stage cancer diagnosis.
Nevertheless, direct identification of rare methylated DNA in the genome remains …

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were known to be risk factors
for HCC, they were suspected to promote its development by eliciting epigenetic changes …

Virtually all patients that succumb to prostate cancer die of metastatic castration-resistant
disease. Although docetaxel is the standard of care for these patients and is associated with …

Prostate cancer (PC) is the most commonly diagnosed nonskin malignancy and the second
most common cause of cancer death among men in the United States. Epigenetics is the …