Oncolytic viruses (OV) are an attractive prospect due to their dual attack mechanism of direct
cell lysis and potentiation of an antitumor immune response. Various oncolytic viral vectors …

In recent years, the biopharmaceutical industry's interest in gene therapy modalities has
increased dramatically. To warrant their quality during manufacturing and …

Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

Polyethyleneimine (PEI) derivatives substituted by lactose, succinic acid or alkyl domains
were evaluated as nonviral gene delivery vectors towards balancing gene transfection and …

While small interfering RNA (siRNA) technology has become a powerful tool that can enable
cancer-specific gene therapy, its translation to the clinic is still hampered by the inability of …

Intervertebral disc degeneration (IVDD) is rising worldwide and leading to significant health
issues and financial strain for patients. Traditional treatments for IVDD can alleviate pain but …

Cancer remains a major global health challenge. Traditional chemotherapy often results in
side effects and drug resistance, necessitating the development of alternative treatment …

Introduction Gene therapy aims to alter the biological properties of cells through the
therapeutic delivery of nucleotides to treat a disease. Although originally developed to treat …

Small molecule, peptide, and protein-based drugs have been developed over decades to
treat various diseases. The importance of gene therapy as an alternative to traditional drugs …

In the realm of gene therapy, a pivotal moment arrived with Paul Berg's groundbreaking
identification of the first recombinant DNA in 1972. This achievement set the stage for future …