Cancer stem cells (CSCs) are a subset of highly tumorigenic cells in tumors. They have
enhanced self-renewal properties, are usually chemo-radioresistant, and can promote tumor …

RON is a receptor tyrosine kinase (RTK) of the MET receptor family that is canonically
involved in mediating growth and inflammatory signaling. RON is expressed at low levels in …

Recepteur d'origine nantais (RON, MST1R) is a single-span transmembrane receptor
tyrosine kinase (RTK) aberrantly expressed in numerous cancers, including various solid …

Lung metastasis is the major cause of death in patients with triple-negative breast cancer
(TNBC). Tumor-associated macrophages (TAMs) represent the M2-like phenotype with …

Background Gastric cancer (GC) is associated with high mortality and heterogeneity and
poses a great threat to humans. Gene therapies for the receptor tyrosine kinase RON and its …

Breast cancer is still a major concern due to its relatively poor prognosis in women, although
there are many approaches being developed for the management of breast cancer …

Abstract Interleukin 35 (IL-35) is a newly discovered inhibitory cytokine of the IL12 family.
More recently, IL-35 was found to be increased in the tumor microenvironment (TME) and …

Background: Aberrant RON signaling is present in numerous cancers including breast
cancer. Evidence suggests that the ligand, hepatocyte growth factor-like (HGFL), is also …

Breast cancers (BCs) are solid tumors composed of heterogeneous tissues consisting of
cancer cells and an ever-changing tumor microenvironment (TME). The TME includes …

Background Cuproptosis, ie, copper-induced programmed cell death, has potential
implications in cancer therapy. However, the impact of the cuproptosis-related gene (CRG) …