Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors

AR Gruber, G Martin, W Keller… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
Expression of mature messenger RNA s (mRNAs) requires appropriate transcription
initiation and termination, as well as pre‐mRNA processing by capping, splicing, cleavage …

Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end

A Ogorodnikov, Y Kargapolova… - Pflügers Archiv-European …, 2016 - Springer
The human transcriptome is highly dynamic, with each cell type, tissue, and organ system
expressing an ensemble of transcript isoforms that give rise to considerable diversity. Apart …

PABPN1 functions as a hub in the assembly of nuclear poly (A) domains that are essential for mouse oocyte development

XX Dai, SB Pi, LW Zhao, YW Wu, JL Shen… - Science …, 2022 - science.org
Growing oocytes store a large amount of maternal mRNA to support the subsequent
“maternal-zygotic transition” process. At present, it is not clear how the growing oocytes store …

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

X Liu, J Freitas, D Zheng, MS Oliveira, M Hoque… - Rna, 2017 - rnajournal.cshlp.org
Alternative polyadenylation (APA) is a mechanism that generates multiple mRNA isoforms
with different 3′ UTRs and/or coding sequences from a single gene. Here, using 3′ region …

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy

S Brachtendorf, RA Wanger, K Birod, D Thomas… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Resistance against chemotherapy is a life-threatening complication in colon cancer therapy.
To increase response rate, new additional targets that contribute to chemoresistance are still …

In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants

Z Liu, Q Liu, X Yang, Y Zhang, M Norris, X Chen… - Genome Biology, 2021 - Springer
Background mRNA processing is critical for gene expression. A challenge in regulating
mRNA processing is how to recognize the actual mRNA processing sites, such as splice and …

A map of 3′ DNA transduction variants mediated by non-LTR retroelements on 3202 human genomes

R Halabian, W Makałowski - Biology, 2022 - mdpi.com
Simple Summary During the transcription of non-LTR retroelements, such as LINEs and
SVAs, the transcriptional termination signal at the 3′ end might be ignored by RNA …

Genome-wide identification of dominant polyadenylation hexamers for use in variant classification

HK Shiferaw, CS Hong, DN Cooper… - Human Molecular …, 2023 - academic.oup.com
Polyadenylation is an essential process for the stabilization and export of mRNAs to the
cytoplasm and the polyadenylation signal hexamer (herein referred to as hexamer) plays a …

3'UTR-Seq analysis of chicken abdominal adipose tissue reveals widespread intron retention in 3'UTR and provides insight into molecular basis of feed efficiency

Z Wang, M Özçam, B Abasht - PloS one, 2022 - journals.plos.org
Feed efficiency (FE) is an important trait in the broiler industry due to its direct correlation to
efficient muscle growth instead of fat deposition. The present study characterized and …

Application of the iPLUS non-coding sequence in improving biopharmaceuticals production

I Reis-Claro, MI Silva, A Moutinho, BC Garcia… - … in Bioengineering and …, 2024 - frontiersin.org
The biotechnological landscape has witnessed significant growth in biological therapeutics
particularly in the field of recombinant protein production. Here we investigate the function of …