Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors
AR Gruber, G Martin, W Keller… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
Expression of mature messenger RNA s (mRNAs) requires appropriate transcription
initiation and termination, as well as pre‐mRNA processing by capping, splicing, cleavage …
initiation and termination, as well as pre‐mRNA processing by capping, splicing, cleavage …
Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end
A Ogorodnikov, Y Kargapolova… - Pflügers Archiv-European …, 2016 - Springer
The human transcriptome is highly dynamic, with each cell type, tissue, and organ system
expressing an ensemble of transcript isoforms that give rise to considerable diversity. Apart …
expressing an ensemble of transcript isoforms that give rise to considerable diversity. Apart …
PABPN1 functions as a hub in the assembly of nuclear poly (A) domains that are essential for mouse oocyte development
XX Dai, SB Pi, LW Zhao, YW Wu, JL Shen… - Science …, 2022 - science.org
Growing oocytes store a large amount of maternal mRNA to support the subsequent
“maternal-zygotic transition” process. At present, it is not clear how the growing oocytes store …
“maternal-zygotic transition” process. At present, it is not clear how the growing oocytes store …
Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster
Alternative polyadenylation (APA) is a mechanism that generates multiple mRNA isoforms
with different 3′ UTRs and/or coding sequences from a single gene. Here, using 3′ region …
with different 3′ UTRs and/or coding sequences from a single gene. Here, using 3′ region …
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy
S Brachtendorf, RA Wanger, K Birod, D Thomas… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Resistance against chemotherapy is a life-threatening complication in colon cancer therapy.
To increase response rate, new additional targets that contribute to chemoresistance are still …
To increase response rate, new additional targets that contribute to chemoresistance are still …
In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants
Background mRNA processing is critical for gene expression. A challenge in regulating
mRNA processing is how to recognize the actual mRNA processing sites, such as splice and …
mRNA processing is how to recognize the actual mRNA processing sites, such as splice and …
A map of 3′ DNA transduction variants mediated by non-LTR retroelements on 3202 human genomes
R Halabian, W Makałowski - Biology, 2022 - mdpi.com
Simple Summary During the transcription of non-LTR retroelements, such as LINEs and
SVAs, the transcriptional termination signal at the 3′ end might be ignored by RNA …
SVAs, the transcriptional termination signal at the 3′ end might be ignored by RNA …
Genome-wide identification of dominant polyadenylation hexamers for use in variant classification
HK Shiferaw, CS Hong, DN Cooper… - Human Molecular …, 2023 - academic.oup.com
Polyadenylation is an essential process for the stabilization and export of mRNAs to the
cytoplasm and the polyadenylation signal hexamer (herein referred to as hexamer) plays a …
cytoplasm and the polyadenylation signal hexamer (herein referred to as hexamer) plays a …
3'UTR-Seq analysis of chicken abdominal adipose tissue reveals widespread intron retention in 3'UTR and provides insight into molecular basis of feed efficiency
Feed efficiency (FE) is an important trait in the broiler industry due to its direct correlation to
efficient muscle growth instead of fat deposition. The present study characterized and …
efficient muscle growth instead of fat deposition. The present study characterized and …
Application of the iPLUS non-coding sequence in improving biopharmaceuticals production
I Reis-Claro, MI Silva, A Moutinho, BC Garcia… - … in Bioengineering and …, 2024 - frontiersin.org
The biotechnological landscape has witnessed significant growth in biological therapeutics
particularly in the field of recombinant protein production. Here we investigate the function of …
particularly in the field of recombinant protein production. Here we investigate the function of …