The metabolically active and perpetually remodeling calcium phosphate–based
endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and …

Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly
reduces lifespan, and its overexpression extends it and protects against various pathological …

Aging is an independent risk factor for CKD, but the molecular mechanisms that link aging
and CKD are not well understood. The antiaging protein Klotho may be an endogenous …

Diabetic kidney disease (DKD) is one of the most common and devastating complications of
diabetic mellitus, and its prevalence is rising worldwide. Klotho, an anti-aging protein, is …

Background αKlotho is the prototypic member of the Klotho family and is most highly
expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its …

Klotho is highly expressed in the kidney and a soluble form of Klotho functions as an
endocrine substance that exerts multiple actions including the modulation of renal solute …

Acute kidney injury, defined by a rapid deterioration of renal function, is a common
complication in hospitalized patients. Among the recent therapeutic options, the use of …

The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called
Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble …

Aging is an inevitable and progressive biological process involving dysfunction and
eventually destruction of every tissue and organ. This process is driven by a tightly regulated …

Plasma phosphate concentration is maintained within a relatively narrow range by control of
renal reabsorption of filtered inorganic phosphate (Pi). Pi reabsorption is a transcellular …