Neurophysiology of HCN channels: from cellular functions to multiple regulations
C He, F Chen, B Li, Z Hu - Progress in neurobiology, 2014 - Elsevier
Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …
involved in multiple physiological processes.•HCN channels are excellent targets of various …
HCN channels: function and clinical implications
EE Benarroch - Neurology, 2013 - AAN Enterprises
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the
superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises 4 …
superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises 4 …
[HTML][HTML] Structures of the human HCN1 hyperpolarization-activated channel
CH Lee, R MacKinnon - Cell, 2017 - cell.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the control of
rhythmic activity in cardiac and neuronal pacemaker cells. In HCN, the polarity of voltage …
rhythmic activity in cardiac and neuronal pacemaker cells. In HCN, the polarity of voltage …
Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons
INTRODUCTION SHANK3 is a scaffolding protein that is enriched in postsynaptic densities
of excitatory synapses but ubiquitously expressed in most cells. SHANK3 gene mutations …
of excitatory synapses but ubiquitously expressed in most cells. SHANK3 gene mutations …
[HTML][HTML] Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain
K Koga, G Descalzi, T Chen, HG Ko, J Lu, S Li, J Son… - Neuron, 2015 - cell.com
Chronic pain can lead to anxiety and anxiety can enhance the sensation of pain.
Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing …
Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing …
[HTML][HTML] Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells
I Tochitsky, A Polosukhina, VE Degtyar, N Gallerani… - Neuron, 2014 - cell.com
Retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are blinding
diseases caused by the degeneration of rods and cones, leaving the remainder of the visual …
diseases caused by the degeneration of rods and cones, leaving the remainder of the visual …
HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond
C Marini, A Porro, A Rastetter, C Dalle, I Rivolta… - Brain, 2018 - academic.oup.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal
excitability and their dysfunction has been linked to epileptogenesis but few individuals with …
excitability and their dysfunction has been linked to epileptogenesis but few individuals with …
Research advances in basic mechanisms of seizures and antiepileptic drug action
W Lasoń, M Chlebicka, K Rejdak - Pharmacological Reports, 2013 - Elsevier
Epilepsy is a common neurological disease but the mechanism of seizure generation has
been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to …
been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to …
cAMP and mitochondria
F Valsecchi, LS Ramos-Espiritu, J Buck… - …, 2013 - journals.physiology.org
Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism
for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial …
for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial …
Voltage-gated ion channels in the PNS: novel therapies for neuropathic pain?
GR Tibbs, DJ Posson, PA Goldstein - Trends in pharmacological sciences, 2016 - cell.com
Neuropathic pain arises from injury to the nervous system. Conditions associated with
neuropathic pain are diverse, and lesions and/or pathological changes in the central …
neuropathic pain are diverse, and lesions and/or pathological changes in the central …