In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications
Since its mechanism discovery in 2012 and the first application for mammalian genome
editing in 2013, CRISPR-Cas9 has revolutionized the genome engineering field and created …
editing in 2013, CRISPR-Cas9 has revolutionized the genome engineering field and created …
Nanobiomaterial vectors for improving gene editing and gene therapy
SW Hu, T Ding, H Tang, H Guo, W Cui, Y Shu - Materials Today, 2023 - Elsevier
With the development of genome editing techniques, gene therapy is becoming a viable
option for the treatment of a variety of human diseases. Genome editing techniques mainly …
option for the treatment of a variety of human diseases. Genome editing techniques mainly …
A duplex CRISPR-Cas9 ribonucleoprotein nanomedicine for colorectal cancer gene therapy
T Wan, Q Pan, C Liu, J Guo, B Li, X Yan, Y Cheng… - Nano Letters, 2021 - ACS Publications
Based on the high frequency of concurrent adenomatous polyposis coli (APC) and KRAS
mutations and their strong cooperative interaction in human colorectal cancer (CRC) …
mutations and their strong cooperative interaction in human colorectal cancer (CRC) …
Guanidyl-Rich Poly (β amino ester) s for Universal Functional Cytosolic protein delivery and clustered regularly interspaced short palindromic repeats (CRISPR) Cas9 …
X Wang, Y Li, X Wang, DM Sandoval, Z He, IL Sáez… - ACS …, 2023 - ACS Publications
Protein therapeutics are highly promising for complex disease treatment. However, the lack
of ideal delivery vectors impedes their clinical use, especially the carriers for in vivo delivery …
of ideal delivery vectors impedes their clinical use, especially the carriers for in vivo delivery …
[HTML][HTML] CRISPR-Cas9 gene therapy for Duchenne muscular dystrophy
Discovery of the CRISPR-Cas (clustered regularly interspaced short palindromic repeat,
CRISPR-associated) system a decade ago has opened new possibilities in the field of …
CRISPR-associated) system a decade ago has opened new possibilities in the field of …
Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome
editing system has been a major technological breakthrough that has brought revolutionary …
editing system has been a major technological breakthrough that has brought revolutionary …
Nucleic acid-based therapeutics for dermal wound healing
Non-healing wounds have long been the subject of scientific and clinical investigations.
Despite breakthroughs in understanding the biology of delayed wound healing, only limited …
Despite breakthroughs in understanding the biology of delayed wound healing, only limited …
3D macrocyclic structure boosted gene delivery: multi-cyclic poly (β-amino Ester) s from step growth polymerization
Y Li, X Wang, Z He, M Johnson… - Journal of the …, 2023 - ACS Publications
The topological structures of polymers play a critical role in determining their gene delivery
efficiency. Exploring novel polymeric structures as gene delivery vectors is thus of great …
efficiency. Exploring novel polymeric structures as gene delivery vectors is thus of great …
Enhanced gene transfection efficacy and safety through granular hydrogel mediated gene delivery process
Although gene therapy has made great achievements in both laboratory research and
clinical translation, there are still challenges such as limited control of drug …
clinical translation, there are still challenges such as limited control of drug …
Preclinical model for phenotypic correction of dystrophic epidermolysis bullosa by in vivo CRISPR-Cas9 delivery using adenoviral vectors
Recessive dystrophic epidermolysis bullosa, a devastating skin fragility disease
characterized by recurrent skin blistering, scarring, and a high risk of developing squamous …
characterized by recurrent skin blistering, scarring, and a high risk of developing squamous …