The most common mood disorders are major depressive disorders and bipolar disorders
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …

Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in
modulation of metabolism and protection against obesity. These important functions are …

Reduced haemodynamic response in the frontotemporal cortices of patients with major
depressive disorder (MDD) has been demonstrated using functional near-infrared …

Humans have long pondered the nature of their mind/brain and, particularly why its
capacities for reasoning, communication and abstract thought are far superior to other …

(1) Background: Prolonged lockdowns with stay-at-home orders have been introduced in
many countries since the outbreak of the COVID-19 pandemic. They have caused a drastic …

Abstract Serotonin (5-HT) and brain-derived neurotrophin factor (BDNF) are known to
modulate behavioral responses to stress and to mediate the therapeutic efficacy of …

Depression is the most common and devastating psychiatric disorder in the world. Its
symptoms, especially during the pandemic, are observed in all age groups. Exercise training …

Background Examining transcriptional regulation by antidepressants in key neural circuits
implicated in depression and understanding the relation to transcriptional mechanisms of …

Abstract Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety,
and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like …

Evidence demonstrates that brain-derived neurotrophic factor (BDNF) has a pivotal role in
the pathogenesis of major depressive disorder (MDD). Precursor-BDNF (proBDNF) and …