Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated
by dysfunctional mitochondria can bring about global changes in gene expression that alters …

Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

Gelsolin superfamily members are Ca2+‐dependent, multidomain regulators of the actin
cytoskeleton. Calcium binding activates gelsolin by inducing molecular gymnastics (large …

Redox control of protein function involves oxidation and reduction of amino acid residues,
but the mechanisms and regulators involved are insufficiently understood. Here, we report …

Eukaryotic cells generate a diversity of actin filament networks in a common cytoplasm to
optimally perform functions such as cell motility, cell adhesion, endocytosis and cytokinesis …

The combinatorial nature of many important mathematical problems, including
nondeterministic-polynomial-time (NP)-complete problems, places a severe limitation on the …

To test the hypothesis that the myosin II motor domain (S1) preferentially binds to specific
subsets of actin filaments in vivo, we expressed GFP-fused S1 with mutations that enhanced …

The contractile actin cortex is important for diverse fundamental cell processes, but little is
known about how the assembly of F-actin and myosin II motors is regulated. We report that …

Troponin is a heterotrimeric Ca 2+-binding protein that has a well-established role in
regulating striated muscle contraction. However, mounting evidence points to novel cellular …

Over the last 25 years, extensive progress has been made in developing a range of
nanotechnological applications where cytoskeletal filaments and molecular motors are key …