Mammalian kidneys are specialized to maintain fluid and electrolyte homeostasis. The
epithelial transport processes along the renal tubule that match output to input have long …

Type 1 and type 2 diabetes, along with their accompanying hyperglycemia, are associated
with a multitude of comorbidities including the development of diabetic kidney disease …

Background Chronic kidney disease (CKD) is a public health problem largely caused by
diabetes. The epidemiology of diabetes mellitus–related CKD (CKD-DM) could provide …

Several factors, including genetics, family history, diet, physical activity, obesity, and insulin
resistance in puberty, appear to increase the risk of type 2 diabetes in youth. Youth-onset …

Hyperuricemia, or elevated serum urate, causes urate kidney stones and gout and also
increases the incidence of many other conditions including renal disease, cardiovascular …

Sexual dimorphism may play a key role in the pathogenesis of diabetic kidney disease
(DKD) and explain differences observed in disease phenotypes, responses to interventions …

While the global prevalence of both type 1 and type 2 diabetes mellitus is similar in men and
women, the consequences of diabetes on associated end-organ complications, including …

Aim Obesity is associated with glomerular hyperfiltration which may precede the
development of overt renal damage. Few studies evaluated the link between inflammasome …

Circulation of urate levels is determined by the balance between urate production and
excretion, homeostasis regulated by the function of urate transporters in key epithelial …

The kidney plays an essential role in homeostasis, accomplished through the regulation of
pH, electrolytes and fluids, by the building blocks of the kidney, the nephrons. One of the …