We have made rapid progress in recent years in identifying the genetic causes of many
human diseases. However, despite this recent progress, our mechanistic understanding of …

All lifeforms have developed highly sophisticated systems equipped to detect altered self
and non-self nucleic acids (NA). In vertebrates, NA-sensing receptors safeguard the integrity …

Nuclear speckles are dynamic membraneless bodies located in the cell nucleus. They
harbor RNAs and proteins, many of which are splicing factors, that together display complex …

Viral DNA genomes have limited coding capacity and therefore harness cellular factors to
facilitate replication of their genomes and generate progeny virions. Studies of viruses and …

Recent discoveries of new large DNA viruses reveal high diversity in their morphologies,
genetic repertoires, and replication strategies. Here, we report the novel features of …

Intrinsically disordered domains represent attractive therapeutic targets because they play
key roles in cancer, as well as in neurodegenerative and infectious diseases. They are …

Viruses reshape the organization of the cell interior to achieve different steps of their cellular
cycle. Particularly, viral replication and assembly often take place in viral factories where …

SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate.
Omicron BA. 2.75 is a subvariant believed to be able to suppress the currently dominant BA …

Epstein-Barr virus (EBV) is a model of herpesvirus latency and epigenetic changes. The
virus preferentially infects human B-lymphocytes (and also other cell types) but does not turn …

Subcellular organization is essential for life. Cells organize their functions into organelles to
concentrate their machinery and supplies for optimal efficiency. Likewise, viruses organize …