The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …

Tissue repair/regeneration, after implantation or injury, involves comprehensive
physiological processes wherein immune responses play a crucial role to enable tissue …

In contrast to non-mammalian vertebrates, mammals and humans have limited innate
capacity for the self-regeneration of tissues and organs owing to differences in genetics …

Periodontitis is a widespread disease characterized by inflammation-induced progressive
damage to the tooth-supporting structures until tooth loss occurs. The regeneration of …

Recently, strategies that can target the underlying mechanisms of phenotype change to
modulate the macrophage immune response from the standpoint of biological science have …

Scaffolds are an integral part of the regenerative medicine field. The contact of biomaterials
with tissue, as was clearly observed over the years, induces immune reactions in a material …

Recent research in the vaccine and immunotherapy fields has revealed that biomaterials
have the ability to activate immune pathways, even in the absence of other immune …

Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic
effects after injury in degenerative diseases. However, limitations such as low cell retention …

Endogenous regeneration aims to rebuild and reinstate tissue function through enlisting
natural self-repairing processes. Promoting endogenous regeneration by reducing tissue …