[HTML][HTML] Understanding PITX2-dependent atrial fibrillation mechanisms through computational models

J Bai, Y Lu, Y Zhu, H Wang, D Yin, H Zhang… - International Journal of …, 2021 - mdpi.com
Atrial fibrillation (AF) is a common arrhythmia. Better prevention and treatment of AF are
needed to reduce AF-associated morbidity and mortality. Several major mechanisms cause …

[HTML][HTML] In Silico Assessment of Class I Antiarrhythmic Drug Effects on Pitx2-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of …

J Bai, Y Zhu, A Lo, M Gao, Y Lu, J Zhao… - International Journal of …, 2021 - mdpi.com
Electrical remodelling as a result of homeodomain transcription factor 2 (Pitx2)-dependent
gene regulation was linked to atrial fibrillation (AF) and AF patients with single nucleotide …

[HTML][HTML] Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation

C García-Padilla, JN Domínguez, V Lodde… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in humans. Genetic and
genomic analyses have recently demonstrated that the homeobox transcription factor Pitx2 …

房颤触发机制研究新进展.

马凌, 马明仁, 张鹏, 景娜, 杨珍珍… - Journal of Practical …, 2021 - search.ebscohost.com
房颤是最常见的快速性房性心律失常, 在心血管疾病中具有较高的发病率和死亡率,
且发病率随着年龄增长而急剧升高, 已成为当今严重危害人类健康的疾病之一 …

[HTML][HTML] Mechanisms underlying pro-arrhythmic abnormalities arising from Pitx2-induced electrical remodelling: An in silico intersubject variability study

Y Zhu, J Bai, A Lo, Y Lu, J Zhao - Annals of translational medicine, 2021 - ncbi.nlm.nih.gov
Background Electrical remodelling as a result of the homeodomain transcription factor 2
(Pitx2)-dependent gene regulation induces atrial fibrillation (AF) with different mechanisms …