meso-Methyl BODIPY Photocages: Mechanisms, Photochemical Properties, and Applications
P Shrestha, D Kand, R Weinstain… - Journal of the American …, 2023 - ACS Publications
meso-methyl BODIPY photocages have recently emerged as an exciting new class of
photoremovable protecting groups (PPGs) that release leaving groups upon absorption of …
photoremovable protecting groups (PPGs) that release leaving groups upon absorption of …
Bioorthogonal chemistry for prodrug activation in vivo
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …
An Activatable Prodrug Nanosystem for Ultrasound‐Driven Multimodal Tumor Therapy and Metastasis Inhibition
J Zheng, H Ge, D Zhou, Q Yao, S Long… - Advanced …, 2023 - Wiley Online Library
Ultrasound, featuring deep tissue penetration and noninvasiveness, offers a new opportunity
to activate functional materials in a tumor‐selective manner. However, very few direct …
to activate functional materials in a tumor‐selective manner. However, very few direct …
[HTML][HTML] The fate of the contact ion pair determines the photochemistry of coumarin-based photocleavable protecting groups
AM Schulte, G Alachouzos, W Szymanski… - Chemical …, 2024 - pubs.rsc.org
Photocleavable protecting groups (PPGs) enable the precise spatiotemporal control over the
release of a payload of interest, in particular a bioactive substance, through light irradiation …
release of a payload of interest, in particular a bioactive substance, through light irradiation …
Photoactivation inducing multifunctional coupling of fluorophore for efficient tumor therapy in situ
W Zhang, Y Lv, F Huo, Y Yun, C Yin - Advanced Materials, 2024 - Wiley Online Library
Photoactivatable molecules, with high‐precision spatialtemporal control, have largely
promoted bioimaging and phototherapy applications of fluorescent dyes. Here, the first …
promoted bioimaging and phototherapy applications of fluorescent dyes. Here, the first …
Light in a Heartbeat: Bond Scission by a Single Photon above 800 nm
M Russo, H Janeková, D Meier… - Journal of the …, 2024 - ACS Publications
Photocages enable scientists to take full control over the activity of molecules using light as
a biocompatible stimulus. Their emerging applications in photoactivated therapies call for …
a biocompatible stimulus. Their emerging applications in photoactivated therapies call for …
Giving the green light to photochemical uncaging of large biomolecules in high vacuum
Y Hua, M Strauss, S Fisher, MFX Mauser, P Manchet… - JACS Au, 2023 - ACS Publications
The isolation of biomolecules in a high vacuum enables experiments on fragile species in
the absence of a perturbing environment. Since many molecular properties are influenced …
the absence of a perturbing environment. Since many molecular properties are influenced …
Mitochondria-targeted COUPY photocages: synthesis and visible-light photoactivation in living cells
M López-Corrales, A Rovira, A Gandioso… - The Journal of …, 2023 - ACS Publications
Releasing bioactive molecules in specific subcellular locations from the corresponding
caged precursors offers great potential in photopharmacology, especially when using …
caged precursors offers great potential in photopharmacology, especially when using …
[HTML][HTML] Cation delocalization and photo-isomerization enhance the uncaging quantum yield of a photocleavable protecting group
AM Schulte, LM Smid, G Alachouzos… - Chemical …, 2024 - pubs.rsc.org
Photocleavable protecting groups (PPGs) enable the light-induced, spatiotemporal control
over the release of a payload of interest. Two fundamental challenges in the design of new …
over the release of a payload of interest. Two fundamental challenges in the design of new …
Polymer mediated light responsive therapeutics delivery system to treat cancer
D Kapoor, N Maheshwari, A Bag, MC Sharma… - European Polymer …, 2024 - Elsevier
The concept of light therapy is not a new one in the treatment of diseases; however, the
concept is relatively new in the delivery of drugs. It is particularly important to mention that …
concept is relatively new in the delivery of drugs. It is particularly important to mention that …