Primary insomnia (PI) is an increasing concern in modern society. Cognitive-behavioral
therapy for insomnia is the first-line recommendation, yet limited availability and cost impede …

Hypertension has become one of the major public health problems in the world. At present,
the pathogenesis of hypertension has still not been completely elucidated. In recent years …

Introduction Insomnia is the second most common mental health issue, also is a social and
financial burden. Insomnia affects the balance between sleep, the immune system, and the …

Background The human gut microbiota (GM) has been recognized as a significant factor in
the development of insomnia, primarily through inflammatory pathways, making it a …

Background Changes in the gut microbiota are closely related to insomnia, but the causal
relationship between them is not yet clear. Objective To clarify the relationship between the …

Abstract Background Prostate cancer (PCa) incidence and mortality rates are rising. Our
previous research has shown that the combination of icariin (ICA) and curcumol (CUR) …

Background Amnestic mild cognitive impairment (aMCI) is a pre-dementia condition
associated with declined cognitive function dominated by memory impairment. The …

Thanks to the advancements in bioinformatics, drugs, and other interventions that modulate
microbes to treat diseases have been emerging continuously. In recent years, an increasing …

Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) initially emerged as oral
antidiabetic medication but were subsequently discovered to exhibit pleiotropic actions …

Background Insomnia persists as a prevalent sleep disorder among middle-aged and older
adults, significantly impacting quality of life and increasing susceptibility to age-related …