Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

New genetic models that target the serotonin system show that transient alterations in
serotonin homeostasis cause permanent changes to adult behaviour and modify the fine …

Voltage-gated sodium (Nav) channels initiate action potentials in most neurons, including
primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non …

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors
and for the dynamic control of movement in response to external stimuli. This review outlines …

The spinal cord is the first relay site in the transmission of nociceptive information from the
periphery to the brain. Sensory signals are transmitted from the periphery by primary afferent …

Taste receptor cells detect chemicals in the oral cavity and transmit this information to taste
nerves, but the neurotransmitter (s) have not been identified. We report that adenosine 5 …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

The mechanisms that generate itch are poorly understood at both the molecular and cellular
levels despite its clinical importance. To explore the peripheral neuronal mechanisms …

Abstract Serotonin [5-hydroxytryptamine (5-HT)] in the central nervous system and in the
periphery has long been considered to have an important role in the control of pain, for …

Chronic itch is a prevalent and debilitating condition for which few effective therapies are
available. We harnessed the natural variation across genetically distinct mouse strains to …