Is serotonin hyperalgesic or analgesic?

C Sommer - Current pain and headache reports, 2006 - Springer
Abstract Serotonin (5-hydroxtryptamine, 5-HT) is an important molecule in pain processing
and modulation. Whether 5-HT has an analgesic or hyperalgesic action depends on the cell …

Prenatal fluoxetine exposure induces life-long serotonin 5-HT3 receptor-dependent cortical abnormalities and anxiety-like behaviour

LA Smit-Rigter, CW Noorlander, L von Oerthel… - …, 2012 - Elsevier
Selective serotonin reuptake inhibitors (SSRIs) are the first choice of drugs to treat
depression and anxiety during pregnancy. However, there is evidence that in utero …

Involvement of mast cells in a mouse model of postoperative pain

SM Oliveira, CC Drewes, CR Silva, G Trevisan… - European journal of …, 2011 - Elsevier
Recent studies have indicated that nearly half of all surgical patients still have inadequate
pain relief; therefore, it is becoming increasingly more important to understand the …

Exposure to particulate matter and carbon monoxide and cause-specific Cardiovascular-Respiratory disease mortality in Ahvaz

M Dastoorpoor, A Riahi, H Yazdaninejhad… - Toxin reviews, 2021 - Taylor & Francis
Recently the short term effects of air pollutants on cardiovascular and respiratory morbidity
and mortality has attracted the attention of many researchers. This study comprehensively …

[引用][C] Pharmacology of pain

P Beaulieu, D Lussier, F Porreca, A Dickenson - 2015 - Lippincott Williams & Wilkins

Complement activation in the peripheral nervous system following the spinal nerve ligation model of neuropathic pain

ME Levin, JG Jin, RR Ji, J Tong, JD Pomonis… - PAIN®, 2008 - Elsevier
Neuroinflammatory and neuroimmune mechanisms, as exemplified by infiltrating immune
cells and activation of resident endothelial/glial cells, respectively, are known to be involved …

Serotonergic neural precursor cell grafts attenuate bilateral hyperexcitability of dorsal horn neurons after spinal hemisection in rat

BC Hains, KM Johnson, MJ Eaton, WD Willis… - Neuroscience, 2003 - Elsevier
Hemisection of the rat spinal cord at thoracic level 13 provides a model of spinal cord injury
that is characterized by chronic pain attributable to hyperexcitability of dorsal horn neurons …

Serotonergic projections govern postnatal neuroblast migration

D García-González, K Khodosevich, Y Watanabe… - Neuron, 2017 - cell.com
In many vertebrates, postnatally generated neurons often migrate long distances to reach
their final destination, where they help shape local circuit activity. Concerted action of …

Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal …

SM Géranton, V Fratto, KK Tochiki, SP Hunt - Molecular pain, 2008 - journals.sagepub.com
Background: Regulation of pain states is, in part, dependent upon plastic changes in
neurones within the superficial dorsal horn. There is also compelling evidence that pain …

Serotonin receptor 5-HT2B mediates serotonin-induced mechanical hyperalgesia

SY Lin, WJ Chang, CS Lin, CY Huang… - Journal of …, 2011 - Soc Neuroscience
Serotonin [5-hydroxytryptamine (5-HT)] released from mast cells or platelets in peripheral
tissues is one of the important inflammatory mediators in pain and hyperalgesia. The …