Single-cell omics assays allow the identification of the type, subtype and functional state of a
single cell. To put such single-cell data in the context of tissues, spatially resolved omics can …

Aldehydes are widespread in the environment, with multiple sources such as food and
beverages, industrial effluents, cigarette smoke, and additives. The toxic effects of exposure …

Long interspersed nuclear element 1 (LINE-1) is the only autonomous retrotransposon in
humans and new integrations are a major source of genetic variation between individuals …

Simple Summary The experimental/pathological observation of genome chaos (including
massive and large-scale translocations, chromothripsis, and polyploidy cancer cells) …

Rare diseases individually affect relatively few people, but as a group they impact
considerable numbers of people. The Rat Genome Database (https://rgd. mcw. edu) is a …

Acute myeloid leukemia (AML) with TP53 mutation is one of the most lethal cancers and
portends an extremely poor prognosis. Based on in silico analyses of druggable genes and …

Fanconi anemia (FA) is a hereditary, DNA repair deficiency disorder caused by pathogenic
variants in any 1 of 22 known genes (FANCA-FANCW). Variants in FANCA account for …

Inverted duplications, also known as foldback inversions, are commonly observed in
cancers and are the major class of chromosome rearrangement recovered from yeast cells …

Alterations in DNA damage response (DDR) and related genes are present in up to 25% of
advanced prostate cancers (PCa). Most frequently altered genes are involved in the …

Neuroblastoma is a pediatric solid tumor characterized by strong clinical heterogeneity.
Although clinical risk-defining genomic alterations exist in neuroblastomas, the mutational …