Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology

S Wahab, S Annadurai, SS Abullais, G Das, W Ahmad… - Plants, 2021 - mdpi.com
There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was
the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and the West from …

Chalcone scaffolds, bioprecursors of flavonoids: Chemistry, bioactivities, and pharmacokinetics

M Rudrapal, J Khan, AAB Dukhyil, RMII Alarousy… - Molecules, 2021 - mdpi.com
Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family
that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant …

Chalcone: a promising bioactive scaffold in medicinal chemistry

G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Molecular mechanisms underlying the anticancer activities of licorice flavonoids

Z Zhang, L Yang, J Hou, S Tian, Y Liu - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Licorice has been commonly used in traditional Chinese
medicine for treatment of gastric, liver, and respiratory disease conditions for more than two …

[HTML][HTML] The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions

AA Gomaa, YA Abdel-Wadood - Phytomedicine plus, 2021 - Elsevier
Background Several recent studies have stated that glycyrrhizin and licorice extract are
present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China …

A review on phytochemicals, pharmacological activities, drug interactions, and associated toxicities of licorice (Glycyrrhiza sp.)

I Husain, K Bala, IA Khan, SI Khan - Food Frontiers, 2021 - Wiley Online Library
Since the beginning, human beings have consistently been using plants and their
components for the prevention and treatment of various ailments. However, in the last few …

Traditional uses, pharmacological effects, and molecular mechanisms of licorice in potential therapy of COVID-19

Q Zhang, H Huang, M Qiu, Z Wu, Z Xin, X Cai… - Frontiers in …, 2021 - frontiersin.org
The current Coronavirus disease 2019 (COVID-19) pandemic has become a global
challenge, and although vaccines have been developed, it is expected that mild to moderate …

Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK …

X Liu, Y Xing, M Li, Z Zhang, J Wang, MH Ri… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Glycyrrhiza glabra L., a traditional medicinal, has a history
of thousands of years. It is widely used in clinic and has been listed in Chinese …

Activation of Nrf2 signaling pathway by natural and synthetic chalcones: A therapeutic road map for oxidative stress

MC Egbujor, S Saha, B Buttari, E Profumo… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key
role in diverse gene expressions responsible for protection against oxidative stress and …

Molecular mechanisms of antiproliferative effects of natural chalcones

R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …