Targeting PI3K/AKT/mTOR signaling pathway in pancreatic cancer: from molecular to clinical aspects

S Stanciu, F Ionita-Radu, C Stefani, D Miricescu… - International journal of …, 2022 - mdpi.com
Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Updates in the diagnosis and management of small-bowel tumors

E Vlachou, A Koffas, C Toumpanakis… - Best Practice & Research …, 2023 - Elsevier
Small-bowel tumors represent a rare entity comprising 0.6% of all new cancer cases in the
US, and only 3% of all gastrointestinal neoplasms. They are a heterogenous group of …

The increasing incidence of neuroendocrine neoplasms worldwide: current knowledge and open issues

RE Rossi, S Massironi - Journal of Clinical Medicine, 2022 - mdpi.com
Neuroendocrine neoplasms (NENs) include a heterogeneous group of tumors derived from
neuroendocrine cells, most commonly arising from the gastro-entero-pancreatic (GEP) and …

Epidemiology of pancreatic neuroendocrine neoplasms: a gender perspective

G Muscogiuri, B Altieri, M Albertelli, A Dotto, R Modica… - Endocrine, 2020 - Springer
Abstract Purpose Pancreatic neuroendocrine neoplasms (PNENs) are a group of clinically
rare and heterogeneous tumors of the pancreas. Currently there are no studies investigating …

[HTML][HTML] Gastroenteropancreatic neuroendocrine neoplasms: A clinical snapshot

CJ Fernandez, M Agarwal, B Pottakkat… - World journal of …, 2021 - ncbi.nlm.nih.gov
Our understanding about the epidemiological aspects, pathogenesis, molecular diagnosis,
and targeted therapies of neuroendocrine neoplasms (NENs) have drastically advanced in …

[HTML][HTML] Current updates and future directions in diagnosis and management of gastroenteropancreatic neuroendocrine neoplasms

A Canakis, LS Lee - World journal of gastrointestinal endoscopy, 2022 - ncbi.nlm.nih.gov
Gastroenteropancreatic neuroendocrine neoplasms are a heterogenous group of rare
neoplasms that are increasingly being discovered, often incidentally, throughout the …

[HTML][HTML] Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms

B Smolkova, A Kataki, J Earl, I Ruz-Caracuel… - Critical Reviews in …, 2022 - Elsevier
Pancreatic neuroendocrine neoplasms (pNENs) are rare cancers with broad challenges for
their management. The main clinical obstacles are the high rate of patients diagnosed at …

Early identification of residual disease after neuroendocrine tumor resection using a liquid biopsy multigenomic mRNA signature (NETest)

IM Modlin, M Kidd, K Oberg, M Falconi… - Annals of Surgical …, 2021 - Springer
Introduction Surgery is the only cure for neuroendocrine tumors (NETs), with R0 resection
being critical for successful tumor removal. Early detection of residual disease is key for …

[HTML][HTML] Developments in interventional management of hepatic metastases from neuroendocrine tumours

AK Clift, R Thomas, A Frilling - Best Practice & Research Clinical …, 2023 - Elsevier
Neuroendocrine tumours commonly metastasise to the liver, particularly those arising from
the intestinal tract and pancreas. Whilst surgery offers the only approach with intent to cure …

Pancreatic neuroendocrine neoplasms: updates on genomic changes in inherited tumour syndromes and sporadic tumours based on WHO classification

H Ishida, AK Lam - Critical Reviews in Oncology/Hematology, 2022 - Elsevier
Pancreatic neuroendocrine neoplasms (PanNENs) are the neuroendocrine neoplasms with
greatest rate of increase in incidence. Approximately 10% of PanNENs arise as inherited …