Background Treatment options for women presenting with triple negative breast cancer
(TNBC) are limited due to the lack of a therapeutic target and as a result, are managed with …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

Objectives The use of doxorubicin, a drug utilised for many years to treat a wide variety of
cancers, has long been limited due to the significant toxicity that can occur not only during …

Oxidative stress and resulting lipid peroxidation is involved in various and numerous
pathological states including inflammation, atherosclerosis, neurodegenerative diseases …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

Breast cancer (BC) is potentially life‐threatening malignancy that still causes high mortality
among women. Scientific research in this field is focused on deeper understanding of …

Different physiological and pathological conditions can perturb protein folding in the
endoplasmic reticulum, leading to a condition known as ER stress. ER stress activates a …

Autophagy is a vital lysosomal degradation and recycling pathway in the eukaryotic cell,
responsible for maintaining an intricate balance between cell survival and cell death …

Photodynamic therapy (PDT) utilizes the destructive power of reactive oxygen species
generated via visible light irradiation of a photosensitive dye accumulated in the cancerous …