Autophagy is a vital lysosomal degradation and recycling pathway in the eukaryotic cell,
responsible for maintaining an intricate balance between cell survival and cell death …

Mounting evidence suggests that reactive oxygen species (ROS) are multifaceted signalling
molecules implicated in a variety of cellular programs during physiological as well as …

Macroautophagy (autophagy) is the major intracellular degradation pathway for long-lived
proteins and organelles. It helps the cell to survive a spectrum of stressful conditions …

Autophagy is a catalytic process of the bulk degradation of long‐lived cellular components,
ultimately resulting in lysosomal digestion within mature cytoplasmic compartments known …

Context: Responses to critical illness, such as excessive inflammation and hyperglycemia,
may trigger detrimental chain reactions that damage cellular proteins and organelles. Such …

Background and Purpose—Despite the rapidly increasing global burden of ischemic stroke,
no therapeutic options for neuroprotection against stroke currently exist. Recent studies …

BACKGROUND & AIMS: Pancreatic adenocarcinoma, among the most lethal human
malignancies, is resistant to current chemotherapies. We previously showed that triptolide …

Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
most prevalent neurodegenerative disease worldwide. The primary pathological hallmarks …

Autophagy, a catabolic process, is activated by conditions of stress and nutrient deprivation,
which occurs to maintain metabolic homeostasis by performing catabolic lysis of excessive …

In response to cellular insult, several pathways can be activated, including necrosis,
apoptosis, and autophagy. Because glucocorticoids (GCs) have been shown to induce both …