Latrepirdine (Dimebon™) enhances autophagy and reduces intracellular GFP-Aβ 42 levels in yeast
PR Bharadwaj, G Verdile, RK Barr… - Journal of …, 2012 - content.iospress.com
Latrepirdine (Dimebon™), an anti-histamine, has shown some benefits in trials of
neurodegenerative diseases characterized by accumulation of aggregated or misfolded …
neurodegenerative diseases characterized by accumulation of aggregated or misfolded …
[HTML][HTML] Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP+-treated SH-SY5Y cells
J Yan, H Ma, X Lai, J Wu, A Liu, J Huang, W Sun… - Journal of Biological …, 2021 - Springer
Background Parkinson's disease (PD) is the second most common neurodegenerative
disease after Alzheimer's disease. The oxidative stress is an important component of the …
disease after Alzheimer's disease. The oxidative stress is an important component of the …
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
Background The outcome of triple negative breast cancer is still poor and requires
improvement with better therapy options. Autophagy has recently been shown to play a role …
improvement with better therapy options. Autophagy has recently been shown to play a role …
Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
SW Ryter, SJ Lee, AMK Choi - Expert review of respiratory …, 2010 - Taylor & Francis
The molecular and cellular mechanisms underlying the pathogenesis of chronic obstructive
pulmonary disease (COPD) remain incompletely understood. We have investigated the …
pulmonary disease (COPD) remain incompletely understood. We have investigated the …
Resistance to hormone therapy in breast cancer cells promotes autophagy and EGFR signaling pathway
KE Siatis, E Giannopoulou, D Manou… - … of Physiology-Cell …, 2023 - journals.physiology.org
Breast cancer is the leading cause of cancer deaths for women worldwide. Endocrine
therapies represent the cornerstone for hormone-dependent breast cancer treatment …
therapies represent the cornerstone for hormone-dependent breast cancer treatment …
[HTML][HTML] Dihydroartemisinin ameliorates learning and memory in Alzheimer's disease through promoting autophagosome-lysosome fusion and autolysosomal …
Y Zhao, Z Long, Y Ding, T Jiang, J Liu, Y Li… - Frontiers in aging …, 2020 - frontiersin.org
Dihydroartemisinin (DHA) is an active metabolite of sesquiterpene trioxane lactone
extracted from Artemisia annua, which is used to treat malaria worldwide. DHA can activate …
extracted from Artemisia annua, which is used to treat malaria worldwide. DHA can activate …
Regulation of autophagy in oxygen-dependent cellular stress
SW Ryter, A MK Choi - Current pharmaceutical design, 2013 - ingentaconnect.com
Oxidative stress caused by supraphysiological production of reactive oxygen species (ROS),
can cause cellular injury associated with protein and lipid oxidation, DNA damage, and …
can cause cellular injury associated with protein and lipid oxidation, DNA damage, and …
Glucosamine protects nucleus pulposus cells and induces autophagy via the mTOR‐dependent pathway
LB Jiang, YL Jin, HR Wang, YQ Jiang… - Journal of Orthopaedic …, 2014 - Wiley Online Library
Although glucosamine has been suggested to be effective in the treatment of osteoarthritis,
its effect on disc degeneration remains unclear. We sought to explore whether glucosamine …
its effect on disc degeneration remains unclear. We sought to explore whether glucosamine …
RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy
YC Ye, HJ Wang, L Yu, SI Tashiro, S Onodera… - International …, 2012 - Elsevier
Tumor necrosis factor alpha (TNFα) induces necroptosis and autophagy; however, the
detailed molecular mechanism is not fully understood. In this study, we found that TNFα …
detailed molecular mechanism is not fully understood. In this study, we found that TNFα …
Involvement of autophagy in cervical, endometrial and ovarian cancer
T Orfanelli, JM Jeong, G Doulaveris… - … journal of cancer, 2014 - Wiley Online Library
Autophagy is an intracellular molecular pathway that maintains cellular homeostasis. A role
for autophagy in the development as well as in the treatment of gynecologic malignancies …
for autophagy in the development as well as in the treatment of gynecologic malignancies …