Latrepirdine (Dimebon™), an anti-histamine, has shown some benefits in trials of
neurodegenerative diseases characterized by accumulation of aggregated or misfolded …

Background Parkinson's disease (PD) is the second most common neurodegenerative
disease after Alzheimer's disease. The oxidative stress is an important component of the …

Background The outcome of triple negative breast cancer is still poor and requires
improvement with better therapy options. Autophagy has recently been shown to play a role …

The molecular and cellular mechanisms underlying the pathogenesis of chronic obstructive
pulmonary disease (COPD) remain incompletely understood. We have investigated the …

Breast cancer is the leading cause of cancer deaths for women worldwide. Endocrine
therapies represent the cornerstone for hormone-dependent breast cancer treatment …

Dihydroartemisinin (DHA) is an active metabolite of sesquiterpene trioxane lactone
extracted from Artemisia annua, which is used to treat malaria worldwide. DHA can activate …

Oxidative stress caused by supraphysiological production of reactive oxygen species (ROS),
can cause cellular injury associated with protein and lipid oxidation, DNA damage, and …

Although glucosamine has been suggested to be effective in the treatment of osteoarthritis,
its effect on disc degeneration remains unclear. We sought to explore whether glucosamine …

Tumor necrosis factor alpha (TNFα) induces necroptosis and autophagy; however, the
detailed molecular mechanism is not fully understood. In this study, we found that TNFα …

Autophagy is an intracellular molecular pathway that maintains cellular homeostasis. A role
for autophagy in the development as well as in the treatment of gynecologic malignancies …