Danshen (Salvia miltiorrhiza) is a traditional medicinal plant widely used in Asian countries
for its pharmacological activities (eg, amelioration of cardiovascular diseases). In this study …

Background Cardiac cell death and generation of oxidative stress contribute to doxorubicin
(DOX)-induced cardiac dysfunction. E3 ligase Nrdp1 plays a critical role in the regulation of …

Abstract Protease-activated receptor 2 (PAR2) is a member of G protein-coupled receptors.
There are two types of PAR2 signaling pathways: Canonical G-protein signaling and β …

Autophagy has a significant role in myocardial injury induced by lipopolysaccharide (LPS).
Estrogen (E2) has been demonstrated to protect cardiomyocytes against apoptosis; …

Recombinant human arginase (rhArg) has been developed for arginine derivation therapy of
cancer and is currently in clinical trials for a variety of malignant solid tumors. In this study …

The purine-derived analogs, roscovitine and purvalanol are selective synthetic inhibitors of
cyclin-dependent kinases (CDKs) induced cell cycle arrest and lead to apoptotic cell death …

Our recent study indicated that angiotensin II (Ang II), the main component of renin-
angiotensin system, participated in the pathogenesis of Parkinson's disease (PD) by …

Drug markets revisits herbal medicines, as historical usages address their therapeutic
efficacies with less adverse effects. Moreover, herbal medicines save both cost and time in …

Background It has been known epidermal growth factor receptor (EGFR) frequently
overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a …

Global gene expression profiling has emerged as a major tool in understanding complex
response patterns of biological systems to perturbations. However, a lack of unbiased …