Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …

Chromatin modifications are linked with regulating patterns of gene expression, but their
causal role and context-dependent impact on transcription remains unresolved. Here we …

Genome‐wide transcriptional activity involves the binding of many transcription factors (TFs)
to thousands of sites in the genome. Pioneer TFs are a class of TFs that maintain open …

The activities of RNA polymerases shape the epigenetic landscape of genomes with
profound consequences for genome integrity and gene expression. A fundamental event …

Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …

Nucleosome positioning can alter the accessibility of DNA-binding proteins to their cognate
DNA elements, and thus its precise control is essential for cell identity and function …

ZNF462 haploinsufficiency is linked to Weiss–Kruszka syndrome, a genetic disorder
characterized by neurodevelopmental defects, including autism. Though conserved in …