Estrogen is a steroid hormone that has critical roles in reproductive development, bone
homeostasis, cardiovascular remodeling and brain functions. However, estrogen also …

Rapid advance in oncology leads to increasing survival of oncologic patients. More and
more of them live long enough to reach either the natural age of menopause or, as a side …

Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …

Background Recent years have witnessed an increasing interest in multi-omics data,
because these data allow for better understanding complex diseases such as cancer on a …

Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

Familial adenomatous polyposis (FAP) is a genetic syndrome characterized by the presence
of multiple polyps in the gastrointestinal tract and a wide range of systemic extra-intestinal …

Although ovarian sex steroids could have protective roles against colorectal cancer (CRC) in
women, little is currently known about their potential anti-tumorigenic effects in men. Hence …

The colon is the largest hormonally active tissue in the human body. It has been known for
over a hundred years that various hormones and bioactive peptides play important roles in …

Background: Next to breast cancer, advanced stage metastatic colon cancer represents a
major cause for mortality in women. Germline or somatic mutations in tumor suppressor …

It is well established that gastrointestinal (GI) cancers are common and devastating diseases
around the world. Despite the significant progress that has been made in the treatment of GI …