During the last decade, a host of epigenetic mechanisms were found to contribute to cancer
and other human diseases. Several genomic studies have revealed that∼ 20% of …

Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …

SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel
nucleosomes and to modulate transcription. Growing evidence indicates that these …

SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP
hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating …

Lung cancer is a devastating disease that remains a top cause of cancer mortality. Despite
improvements with targeted and immunotherapies, the majority of patients with lung cancer …

SMARCA4, also known as transcription activator, is an ATP-dependent catalytic subunit of
SWI/SNF (SWItch/Sucrose NonFermentable) chromatin-remodeling complexes that …

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling
processes that are critical for differentiation and proliferation. Not surprisingly, loss of …

The occurrence of inactivating mutations in SWI/SNF chromatin-remodeling genes in
common cancers has attracted a great deal of interest. However, mechanistic strategies to …

Rhabdoid tumors of early infancy are highly aggressive with consequent poor prognosis.
Most cases show inactivation of the SMARCB1 (also known as INI1 and hSNF5) tumor …

SMARCA2 is an attractive synthetic lethality target for human cancers with SMARCA4
deficiency. Herein, we report the design, synthesis, and biological evaluation of selective …