Advances in antibody-based therapy in oncology
S Zinn, R Vazquez-Lombardi, C Zimmermann, P Sapra… - Nature cancer, 2023 - nature.com
Monoclonal antibodies are a growing class of targeted cancer therapeutics, characterized by
exquisite specificity, long serum half-life, high affinity and immune effector functions. In this …
exquisite specificity, long serum half-life, high affinity and immune effector functions. In this …
Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy
Humoral immune responses are characterized by complex mixtures of polyclonal antibody
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
[HTML][HTML] Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Muscle-specific tyrosine kinase myasthenia gravis (MuSK MG) is an autoimmune disease
that causes life-threatening muscle weakness due to anti-MuSK autoantibodies that disrupt …
that causes life-threatening muscle weakness due to anti-MuSK autoantibodies that disrupt …
[HTML][HTML] Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains
L Abendstein, DJ Dijkstra, RTN Tjokrodirijo… - Nature …, 2023 - nature.com
IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …
enhanced effector functions, including highly efficient pathogen neutralisation and …
[HTML][HTML] Immunoglobulin germline gene variation and its impact on human disease
Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
[HTML][HTML] Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1)
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …
[HTML][HTML] Afucosylated IgG responses in humans–structural clues to the regulation of humoral immunity
JJ Oosterhoff, MD Larsen, CE van der Schoot… - Trends in …, 2022 - cell.com
Healthy immune responses require efficient protection without excessive inflammation.
Recent discoveries on the degree of fucosylation of a human N-linked glycan at a conserved …
Recent discoveries on the degree of fucosylation of a human N-linked glycan at a conserved …
[HTML][HTML] Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma
Background Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19
vaccine trials. However, nAb response against SARS-CoV-2, when present, decays rapidly …
vaccine trials. However, nAb response against SARS-CoV-2, when present, decays rapidly …
A novel CD19/CD22/CD3 trispecific antibody enhances therapeutic efficacy and overcomes immune escape against B-ALL
L Zhao, S Li, X Wei, X Qi, D Liu, L Liu… - Blood, The Journal …, 2022 - ashpublications.org
The bispecific T-cell engager (BiTE) blinatumomab against CD19 and CD3 has emerged as
the most successful bispecific antibody (bsAb) to date; however, a significant proportion of …
the most successful bispecific antibody (bsAb) to date; however, a significant proportion of …