Advances in antibody-based therapy in oncology

S Zinn, R Vazquez-Lombardi, C Zimmermann, P Sapra… - Nature cancer, 2023 - nature.com
Monoclonal antibodies are a growing class of targeted cancer therapeutics, characterized by
exquisite specificity, long serum half-life, high affinity and immune effector functions. In this …

Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy

F Nimmerjahn, G Vidarsson, MS Cragg - Nature immunology, 2023 - nature.com
Humoral immune responses are characterized by complex mixtures of polyclonal antibody
species varying in their isotype, target epitope specificity and affinity. Posttranslational …

The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

[HTML][HTML] Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

S Oh, X Mao, S Manfredo-Vieira, J Lee, D Patel… - Nature …, 2023 - nature.com
Muscle-specific tyrosine kinase myasthenia gravis (MuSK MG) is an autoimmune disease
that causes life-threatening muscle weakness due to anti-MuSK autoantibodies that disrupt …

[HTML][HTML] Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

L Abendstein, DJ Dijkstra, RTN Tjokrodirijo… - Nature …, 2023 - nature.com
IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …

[HTML][HTML] Immunoglobulin germline gene variation and its impact on human disease

I Mikocziova, V Greiff, LM Sollid - Genes & Immunity, 2021 - nature.com
Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …

[HTML][HTML] Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells

NL Board, Z Yuan, F Wu, M Moskovljevic, M Ravi… - Nature …, 2024 - nature.com
The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1)
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …

[HTML][HTML] Afucosylated IgG responses in humans–structural clues to the regulation of humoral immunity

JJ Oosterhoff, MD Larsen, CE van der Schoot… - Trends in …, 2022 - cell.com
Healthy immune responses require efficient protection without excessive inflammation.
Recent discoveries on the degree of fucosylation of a human N-linked glycan at a conserved …

[HTML][HTML] Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma

FY Tso, SJ Lidenge, LK Poppe, PB Peña, SR Privatt… - PLoS …, 2021 - journals.plos.org
Background Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19
vaccine trials. However, nAb response against SARS-CoV-2, when present, decays rapidly …

A novel CD19/CD22/CD3 trispecific antibody enhances therapeutic efficacy and overcomes immune escape against B-ALL

L Zhao, S Li, X Wei, X Qi, D Liu, L Liu… - Blood, The Journal …, 2022 - ashpublications.org
The bispecific T-cell engager (BiTE) blinatumomab against CD19 and CD3 has emerged as
the most successful bispecific antibody (bsAb) to date; however, a significant proportion of …